PMID- 30875840
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 3
DP  - 2019 Mar 14
TI  - Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in 
      Diabetic Rodent Models.
LID - 10.3390/nu11030629 [doi]
LID - 629
AB  - Hedychium coronarium has a long history of use worldwide as a food and in folk 
      medicine. In this study, we aimed to investigate the effect of an aqueous extract 
      of H. coronarium leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of 
      animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar 
      rats; N = 8) and C57BKSdb/db mice (N = 5). After treatment with HC for 28 days, 
      glucose tolerance improved in both of the diabetic animal models. As significant 
      effects were shown after 14 days of treatment in the STZ-induced T2DM model, we 
      carried out the experiments with it. After 28 days of treatment with HC, the 
      levels of cholesterol, triglyceride, high-density lipoprotein, and low-density 
      lipoprotein were significantly improved in the STZ-induced T2DM model. The 
      lesions degree of islet beta-cells was decreased after the HC treatment. Although 
      the insulin level increased moderately, the aldosterone level was significantly 
      decreased in the HC-treated groups, suggesting that aldosterone might play an 
      important role in this effect. In summary, HC is a natural product and it is 
      worth exploring its effect on T2DM.
FAU - Tse, Ling-Shan
AU  - Tse LS
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, 
      Taiwan. zoetsels@gmail.com.
FAU - Liao, Po-Lin
AU  - Liao PL
AD  - Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical 
      Sciences, National Yang-Ming University, Taipei 112, Taiwan. 
      plliao0825@gmail.com.
FAU - Tsai, Chi-Hao
AU  - Tsai CH
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, 
      Taiwan. d01447001@ntu.edu.tw.
AD  - Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 
      100, Taiwan. d01447001@ntu.edu.tw.
FAU - Li, Ching-Hao
AU  - Li CH
AD  - Department of Physiology, School of Medicine, Graduate Institute of Medical 
      Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. 
      bros22@tmu.edu.tw.
FAU - Liao, Jiunn-Wang
AU  - Liao JW
AUID- ORCID: 0000-0001-7374-1203
AD  - Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, 
      Taichung 402, Taiwan. jwliao@dragon.nchu.edu.tw.
FAU - Kang, Jaw-Jou
AU  - Kang JJ
AD  - Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical 
      Sciences, National Yang-Ming University, Taipei 112, Taiwan. jjkang@ym.edu.tw.
FAU - Cheng, Yu-Wen
AU  - Cheng YW
AUID- ORCID: 0000-0003-3714-0464
AD  - School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, 
      Taiwan. ywcheng@tmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20190314
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
RN  - 4964P6T9RB (Aldosterone)
RN  - 5W494URQ81 (Streptozocin)
MH  - Aldosterone/blood
MH  - Animals
MH  - Blood Glucose/*drug effects
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/blood
MH  - Plant Extracts/*pharmacology
MH  - Plant Leaves/chemistry
MH  - Rats
MH  - Streptozocin
MH  - Zingiberaceae/*chemistry
PMC - PMC6470712
OTO - NOTNLM
OT  - Hedychium coronarium
OT  - aldosterone
OT  - folk medicine
OT  - metabolic syndrome
OT  - streptozotocin
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest. The study design, operation, data 
      analyses, and conclusions were not influenced by the sponsor.
EDAT- 2019/03/17 06:00
MHDA- 2019/07/26 06:00
PMCR- 2019/03/01
CRDT- 2019/03/17 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/03/07 00:00 [revised]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/03/17 06:00 [entrez]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - nu11030629 [pii]
AID - nutrients-11-00629 [pii]
AID - 10.3390/nu11030629 [doi]
PST - epublish
SO  - Nutrients. 2019 Mar 14;11(3):629. doi: 10.3390/nu11030629.