PMID- 30875947
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20231011
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 17
IP  - 3
DP  - 2019 Mar 15
TI  - Hydrophilic Glycoproteins of an Edible Green Alga Capsosiphon fulvescens Prevent 
      Aging-Induced Spatial Memory Impairment by Suppressing GSK-3beta-Mediated ER Stress 
      in Dorsal Hippocampus.
LID - 10.3390/md17030168 [doi]
LID - 168
AB  - Endoplasmic reticulum (ER) stress is involved in various neurodegenerative 
      disorders. We previously found that Capsosiphon fulvescens (C. fulvescens) crude 
      proteins enhance spatial memory by increasing the expression of brain-derived 
      neurotrophic factor (BDNF) in rat dorsal hippocampus. The present study 
      investigated whether the chronic oral administration of hydrophilic C. fulvescens 
      glycoproteins (Cf-hGP) reduces aging-induced cognitive dysfunction by regulating 
      ER stress in the dorsal hippocampus. The oral administration of Cf-hGP (15 
      mg/kg/day) for four weeks attenuated the aging-induced increase in ER stress 
      response protein glucose-regulated protein 78 (GRP78) in the synaptosome of the 
      dorsal hippocampus; this was attenuated by the function-blocking anti-BDNF 
      antibody (1 mug/muL) and a matrix metallopeptidase 9 inhibitor 1 (5 muM). 
      Aging-induced GRP78 expression was associated with glycogen synthase kinase-3 
      beta (GSK-3beta) (Tyr216)-mediated c-Jun N-terminal kinase phosphorylation, which 
      was downregulated upon Cf-hGP administration. The Cf-hGP-induced increase in 
      GSK-3beta (Ser9) phosphorylation was downregulated by inhibiting tyrosine receptor 
      kinase B and extracellular signal-regulated kinase (ERK)1/2 with cyclotraxin-B 
      (200 nM) and SL327 (10 muM), respectively. Cf-hGP administration or the inhibition 
      of ER stress with salubrinal (1 mg/kg, i.p.) significantly decreased 
      aging-induced spatial memory impairment. These findings suggest that the 
      activation of the synaptosomal BDNF-ERK1/2 signaling in the dorsal hippocampus by 
      Cf-hGP attenuates age-dependent ER stress-induced cognitive dysfunction.
FAU - Oh, Jeong Hwan
AU  - Oh JH
AD  - Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Korea. 
      ojhwan55@pknu.ac.kr.
FAU - Nam, Taek-Jeong
AU  - Nam TJ
AUID- ORCID: 0000-0002-5954-6935
AD  - Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Korea. 
      namtj@pknu.ac.kr.
LA  - eng
GR  - 2012R1A6A1028677/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20190315
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycoproteins)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (glucose-regulated proteins)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, rat)
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Chlorophyta/*chemistry
MH  - Cognitive Aging
MH  - Cognitive Dysfunction/drug therapy
MH  - Endoplasmic Reticulum Stress/*drug effects
MH  - Glycogen Synthase Kinase 3 beta/antagonists & inhibitors/*metabolism
MH  - Glycoproteins/*pharmacology
MH  - HSP70 Heat-Shock Proteins/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - MAP Kinase Kinase 4/metabolism
MH  - MAP Kinase Signaling System/drug effects
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Membrane Proteins/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Spatial Memory/*drug effects
PMC - PMC6470841
OTO - NOTNLM
OT  - Capsosiphon fulvescens
OT  - aging
OT  - cognitive dysfunction
OT  - endoplasmic reticulum stress
OT  - glycoproteins
COIS- The authors declare no conflicts of interest.
EDAT- 2019/03/17 06:00
MHDA- 2019/07/30 06:00
PMCR- 2019/03/01
CRDT- 2019/03/17 06:00
PHST- 2019/02/09 00:00 [received]
PHST- 2019/02/27 00:00 [revised]
PHST- 2019/03/12 00:00 [accepted]
PHST- 2019/03/17 06:00 [entrez]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - md17030168 [pii]
AID - marinedrugs-17-00168 [pii]
AID - 10.3390/md17030168 [doi]
PST - epublish
SO  - Mar Drugs. 2019 Mar 15;17(3):168. doi: 10.3390/md17030168.