PMID- 30877712
OWN - NLM
STAT- MEDLINE
DCOM- 20200422
LR  - 20200422
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 43
IP  - 3
DP  - 2019 Jun
TI  - Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular 
      Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study.
PG  - 350-367
LID - 10.4093/dmj.2018.0108 [doi]
AB  - BACKGROUND: Increasing evidence has shown that visit-to-visit variability (VVV) 
      of blood pressure (BP) is associated with an increased risk of cardiovascular 
      disease (CVD). The objective of this study was to evaluate the impact of VVV of 
      systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of 
      CVD among patients with type 2 diabetes mellitus (T2DM) in China. METHODS: We 
      conducted a retrospective cohort study of 10,163 T2DM patients who were not 
      previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, 
      China. The VVV of BP was calculated using five metrics, including standard 
      deviation (SD), coefficient of variation (CV), variation independent of mean, 
      average real variability, and successive variability (SV) of measurements, 
      obtained over a 24-month measurement period. Hazard ratios and 95% confidence 
      intervals (CIs) were estimated by Cox proportional hazards regression models for 
      the associations of variability in BP with risk of CVD. RESULTS: A total of 894 
      CVD events were observed during a median follow-up of 49.5 months. The hazard 
      ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) 
      compared with patients in the lowest quintile. The association between higher VVV 
      of DBP and risk of CVD was not consistent across different metrics and 
      sensitivity analyses. CONCLUSION: Higher VVV of SBP was associated with an 
      increased risk of CVD, irrespective of the mean SBP level. Future studies are 
      needed to confirm these findings.
CI  - Copyright (c) 2019 Korean Diabetes Association.
FAU - Yu, Zhe Bin
AU  - Yu ZB
AUID- ORCID: 0000-0001-9392-5624
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Li, Die
AU  - Li D
AUID- ORCID: 0000-0003-2000-2372
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Chen, Xue Yu
AU  - Chen XY
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Zheng, Pei Wen
AU  - Zheng PW
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Lin, Hong Bo
AU  - Lin HB
AD  - Center for Disease Control and Prevention of Yinzhou District, Ningbo, China.
FAU - Tang, Meng Ling
AU  - Tang ML
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Jin, Ming Juan
AU  - Jin MJ
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
FAU - Wang, Jian Bing
AU  - Wang JB
AUID- ORCID: 0000-0002-5571-2174
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
AD  - Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, 
      China. wangjianbing@zju.edu.cn.
FAU - Chen, Kun
AU  - Chen K
AUID- ORCID: 0000-0003-1162-6896
AD  - Department of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou, China.
AD  - Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, 
      China. ck@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190306
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
MH  - Aged
MH  - *Blood Pressure
MH  - Cardiovascular Diseases/complications/*diagnosis/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC6581546
OTO - NOTNLM
OT  - Blood pressure
OT  - Cardiovascular diseases
OT  - Diabetes mellitus, type 2
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2019/03/17 06:00
MHDA- 2019/03/17 06:01
PMCR- 2019/06/01
CRDT- 2019/03/17 06:00
PHST- 2018/06/29 00:00 [received]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2019/03/17 06:01 [medline]
PHST- 2019/03/17 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 43.e15 [pii]
AID - 10.4093/dmj.2018.0108 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2019 Jun;43(3):350-367. doi: 10.4093/dmj.2018.0108. Epub 2019 
      Mar 6.