PMID- 30877923
OWN - NLM
STAT- MEDLINE
DCOM- 20190710
LR  - 20191210
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 225
DP  - 2019 Jun
TI  - Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem 
      mass spectrometry as an alternative to gas chromatography tandem mass 
      spectrometry for the determination of polychlorinated biphenyls and 
      polybrominated diphenyl ethers.
PG  - 288-294
LID - S0045-6535(19)30443-6 [pii]
LID - 10.1016/j.chemosphere.2019.03.011 [doi]
AB  - A method for the analysis of polychlorinated biphenyls (PCBs) and polybrominated 
      diphenyl ethers (PBDEs) in serum was developed using gas chromatography coupled 
      to tandem mass spectrometry with atmospheric pressure chemical ionization 
      (GC-APCI-MS/MS). The ionization and fragmentation performance of APCI were 
      evaluated and compared with those of electron ionization (EI). In contrast to 
      extensive fragmentation caused by EI with high energy, soft ionization achieved 
      by APCI produced mass spectra dominated by molecular ions from the first stage of 
      MS analysis. Better sensitivity and selectivity achieved by the GC-APCI-MS/MS 
      method allowed to analyze serum samples with a low volume (100 muL). The limits of 
      detection (LODs) ranged from 0.067 to 14 pg/mL for the analysis in serum samples. 
      The developed method was evaluated at three spiking levels (0.05, 0.5 and 5 ng/mL 
      for PCBs), showing good recoveries and repeatability. The recoveries ranged from 
      74.0% to 130.5%, and the relative standard deviations (RSDs) were less than 20%, 
      for all analytes. The determination of PCBs and PBDEs in the human serum samples 
      by GC-APCI-MS/MS was compared with gas chromatography-tandem mass spectrometry 
      with EI (GC-EI-MS/MS). BDE-99 and BDE-100 were successfully quantified by 
      GC-APCI-MS/MS, while these two PBDE congeners were not detected by GC-EI-MS/MS. 
      The GC-APCI-MS/MS method had a clear advantage when analyzing compounds at low 
      levels.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Fang, Jing
AU  - Fang J
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong SAR, China.
FAU - Zhao, Hongzhi
AU  - Zhao H
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong SAR, China.
FAU - Zhang, Yanhao
AU  - Zhang Y
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong SAR, China.
FAU - Wong, Minghung
AU  - Wong M
AD  - Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, 
      School of Environmental Science and Engineering, Southern University of Science 
      and Technology, Shenzhen, China; Consortium on Health, Environment, Education and 
      Research (CHEER), The Education University of Hong Kong, Hong Kong SAR, China.
FAU - He, Yu
AU  - He Y
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong SAR, China; MOE Key Laboratory 
      for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou 
      University, Fuzhou, 350116, China.
FAU - Sun, Qianqian
AU  - Sun Q
AD  - MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of 
      Chemistry, Fuzhou University, Fuzhou, 350116, China.
FAU - Xu, Shunqing
AU  - Xu S
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health 
      (Incubation), School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      xust@hust.edu.cn.
FAU - Cai, Zongwei
AU  - Cai Z
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Hong Kong SAR, China. Electronic 
      address: zwcai@hkbu.edu.hk.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20190308
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Atmospheric Pressure
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Limit of Detection
MH  - Polychlorinated Biphenyls/*blood
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - APCI
OT  - Human serum
OT  - PBDEs
OT  - PCBs
EDAT- 2019/03/17 06:00
MHDA- 2019/07/11 06:00
CRDT- 2019/03/17 06:00
PHST- 2018/07/16 00:00 [received]
PHST- 2019/02/18 00:00 [revised]
PHST- 2019/03/03 00:00 [accepted]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2019/07/11 06:00 [medline]
PHST- 2019/03/17 06:00 [entrez]
AID - S0045-6535(19)30443-6 [pii]
AID - 10.1016/j.chemosphere.2019.03.011 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Jun;225:288-294. doi: 10.1016/j.chemosphere.2019.03.011. Epub 
      2019 Mar 8.