PMID- 30877950
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20200806
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 119
DP  - 2019 Jul
TI  - Cytokine profile of macrophage activation syndrome associated with Kawasaki 
      disease.
PG  - 52-56
LID - S1043-4666(19)30073-0 [pii]
LID - 10.1016/j.cyto.2019.03.001 [doi]
AB  - The present study aimed to assess the kinetics of cytokine release and compare 
      the accuracy of serum biomarkers for the diagnosis of macrophage activation 
      syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, 
      interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I 
      (sTNFR-I) and sTNFR-II levels were determined using enzyme-linked immunosorbent 
      assay in 78 patients with KD, including five with MAS. Results were compared to 
      the clinical features of MAS. Serum neopterin, IL-18, sTNFR-II levels and 
      sTNFR-II/I ratio were significantly elevated in KD patients with MAS compared to 
      those in the acute phase. Receiver operating characteristic curve analysis 
      revealed areas under the curve and cutoff values of neopterin, IL-18, sTNFR-II 
      levels and sTNFR-II/I ratio were 0.9750/30.0 nmol/L, 0.9813/1165 ng/mL, 
      0.9969/16,600 pg/mL and 0.9875/4.475, respectively. Serum sTNFR-II levels 
      correlated positively with disease activity. These findings indicate that 
      overproduction of interferon (IFN)-gamma and TNF-alpha reflected by increased serum 
      levels of neopterin and sTNFR-II are closely associated with the pathogenesis of 
      MAS associated with KD. Serum sTNFR-II levels might be a useful marker to 
      diagnose the transition to MAS.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Jinkawa, Asumi
AU  - Jinkawa A
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Shimizu, Masaki
AU  - Shimizu M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. 
      Electronic address: shimizum@staff.kanazawa-u.ac.jp.
FAU - Nishida, Keigo
AU  - Nishida K
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Kaneko, Shuya
AU  - Kaneko S
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Usami, Masaaki
AU  - Usami M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Sakumura, Naoto
AU  - Sakumura N
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Irabu, Hitoshi
AU  - Irabu H
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Takakuwa, Maiko
AU  - Takakuwa M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Inoue, Natsumi
AU  - Inoue N
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Mizuta, Mao
AU  - Mizuta M
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Ikawa, Yasuhiro
AU  - Ikawa Y
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Fujita, Shuhei
AU  - Fujita S
AD  - Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan.
FAU - Yachie, Akihiro
AU  - Yachie A
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190314
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Macrophage Activation Syndrome/*blood
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*blood
MH  - ROC Curve
OTO - NOTNLM
OT  - Kawasaki disease
OT  - Macrophage activation syndrome
OT  - Soluble tumour necrosis factor receptor type II
EDAT- 2019/03/17 06:00
MHDA- 2020/08/07 06:00
CRDT- 2019/03/17 06:00
PHST- 2019/01/22 00:00 [received]
PHST- 2019/03/01 00:00 [revised]
PHST- 2019/03/05 00:00 [accepted]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2019/03/17 06:00 [entrez]
AID - S1043-4666(19)30073-0 [pii]
AID - 10.1016/j.cyto.2019.03.001 [doi]
PST - ppublish
SO  - Cytokine. 2019 Jul;119:52-56. doi: 10.1016/j.cyto.2019.03.001. Epub 2019 Mar 14.