PMID- 30877977
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 121
DP  - 2019 Jun
TI  - Consensus on the methodology for experimental studies in allergic rhinitis.
PG  - 68-71
LID - S0165-5876(19)30130-2 [pii]
LID - 10.1016/j.ijporl.2019.03.009 [doi]
AB  - OBJECTIVES: Allergic rhinitis (AR) is a symptomatic disorder of the nose induced 
      by allergen exposure, which triggers immunoglobulin E (IgE)-mediated inflammation 
      of the nasal membranes. Allergic rhinitis is one of the most common health 
      problems and has a major effect on the quality of life. METHODS: In this review, 
      we aimed to provide a consensus for experimental studies on allergic rhinitis in 
      terms of allergic rhinitis models. For this purpose, we searched for experimental 
      studies in the PubMed, Proquest Central, and Google electronic databases over a 
      20-year period from the current time (1996-2016). The literature survey was 
      performed using keywords including "allergic rhinitis", "experimental", "animal", 
      "model", "rat", "rabbit", "guinea pig", and "mice" alone or in various 
      combinations. The search identified a total of 285 papers, which were included in 
      this review. RESULTS: It is vital to select a suitable animal for an allergic 
      model. Rodents like rats, guinea pigs, and mice can produce allergen-specific 
      antibodies with the use of adjuvants. Rats are cheap and the vast majority of the 
      allergen-specific antibodies are immunoglobulin E (IgE). Still, intraperitoneal 
      sensitization is inescapable and adjuvants are required for sensitization. Rats, 
      mice, rabbits, and guinea pigs can be utilized for this reason. CONCLUSION: This 
      review presented allergic rhinitis models in rats, mice, guinea pigs, and 
      rabbits. Using these methods, researchers may perform well-designed studies.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Kar, Murat
AU  - Kar M
AD  - ENT Specialist in Kumluca State Hospital, ENT Clinics, Antalya, Turkey. 
      Electronic address: drmuratkar@gmail.com.
FAU - Bayar Muluk, Nuray
AU  - Bayar Muluk N
AD  - ENT Department, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey. 
      Electronic address: nbayarmuluk@yahoo.com.
FAU - Bafaqeeh, Sameer Ali
AU  - Bafaqeeh SA
AD  - ENT Department, King Saud University, Riyadh, Saudi Arabia. Electronic address: 
      bafaqeeh@hotmail.com.
FAU - Cingi, Cemal
AU  - Cingi C
AD  - ENT Department, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, 
      Turkey. Electronic address: ccingi@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190309
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Consensus
MH  - *Disease Models, Animal
MH  - Guinea Pigs
MH  - Immunoglobulin E/immunology
MH  - Mice
MH  - Nasal Mucosa/immunology
MH  - Rabbits
MH  - Rats
MH  - Rhinitis, Allergic/immunology/*veterinary
OTO - NOTNLM
OT  - Allergic rhinitis (AR)
OT  - Animal model
OT  - Guinea pigs
OT  - Mice
OT  - Rabbits
OT  - Rats
EDAT- 2019/03/17 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/03/17 06:00
PHST- 2018/11/19 00:00 [received]
PHST- 2019/03/06 00:00 [accepted]
PHST- 2019/03/17 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/03/17 06:00 [entrez]
AID - S0165-5876(19)30130-2 [pii]
AID - 10.1016/j.ijporl.2019.03.009 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2019 Jun;121:68-71. doi: 
      10.1016/j.ijporl.2019.03.009. Epub 2019 Mar 9.