PMID- 30878405
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200508
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 22
DP  - 2019
TI  - "The effect of tDCS on functional connectivity in primary progressive aphasia" 
      NeuroImage: Clinical, volume 19 (2018), pages 703-715.
PG  - 101734
LID - S2213-1582(19)30084-1 [pii]
LID - 10.1016/j.nicl.2019.101734 [doi]
LID - 101734
AB  - Transcranial direct current stimulation (tDCS) is an innovative technique 
      recently shown to improve language outcomes even in neurodegenerative conditions 
      such as primary progressive aphasia (PPA), but the underlying brain mechanisms 
      are not known. The present study tested whether the additional language gains 
      with repetitive tDCS (over sham) in PPA are caused by changes in functional 
      connectivity between the stimulated area (the left inferior frontal gyrus (IFG)) 
      and the rest of the language network. We scanned 24 PPA participants (11 female) 
      before and after language intervention (written naming/spelling) with a 
      resting-state fMRI sequence and compared changes before and after three weeks of 
      tDCS or sham coupled with language therapy. We correlated changes in the language 
      network as well as in the default mode network (DMN) with language therapy 
      outcome measures (letter accuracy in written naming). Significant tDCS effects in 
      functional connectivity were observed between the stimulated area and other 
      language network areas and between the language network and the DMN. TDCS over 
      the left IFG lowered the connectivity between the above pairs. Changes in 
      functional connectivity correlated with improvement in language scores (letter 
      accuracy as a proxy for written naming) evaluated before and after therapy. These 
      results suggest that one mechanism for anodal tDCS over the left IFG in PPA is a 
      decrease in functional connectivity (compared to sham) between the stimulated 
      site and other posterior areas of the language network. These results are in line 
      with similar decreases in connectivity observed after tDCS over the left IFG in 
      aging and other neurodegenerative conditions.
CI  - Copyright (c) 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Ficek, Bronte N
AU  - Ficek BN
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA.
FAU - Wang, Zeyi
AU  - Wang Z
AD  - Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 
      21287, USA.
FAU - Zhao, Yi
AU  - Zhao Y
AD  - Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 
      21287, USA.
FAU - Webster, Kimberly T
AU  - Webster KT
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School 
      of Medicine, Baltimore, MD 21287, USA.
FAU - Desmond, John E
AU  - Desmond JE
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA.
FAU - Hillis, Argye E
AU  - Hillis AE
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 
      21218, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins 
      School of Medicine, Baltimore, MD 21287, USA.
FAU - Frangakis, Constantine
AU  - Frangakis C
AD  - Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 
      21287, USA; Department of Radiology, Johns Hopkins School of Medicine, Baltimore, 
      MD 21287, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins 
      School of Medicine, Baltimore, MD 21287, USA.
FAU - Faria, Andreia Vasconcellos
AU  - Faria AV
AD  - Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA.
FAU - Caffo, Brian
AU  - Caffo B
AD  - Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD 
      21287, USA.
FAU - Tsapkini, Kyrana
AU  - Tsapkini K
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, 
      USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 
      21218, USA. Electronic address: tsapkini@jhmi.edu.
LA  - eng
GR  - P50 DC014664/DC/NIDCD NIH HHS/United States
GR  - R01 DC011317/DC/NIDCD NIH HHS/United States
GR  - R01 AI140854/AI/NIAID NIH HHS/United States
GR  - R01 DC014475/DC/NIDCD NIH HHS/United States
GR  - R01 DC005375/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Published Erratum
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190314
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
EFR - Neuroimage Clin. 2018 May 21;19:703-715. PMID: 30009127
PMC - PMC6543522
OTO - NOTNLM
OT  - Functional connectivity
OT  - Neurodegenerative diseases
OT  - Primary progressive aphasia (PPA)
OT  - Resting-state fMRI (rsfMRI)
OT  - Transcranial direct current stimulation (tDCS)
EDAT- 2019/03/18 06:00
MHDA- 2019/03/18 06:01
PMCR- 2019/03/14
CRDT- 2019/03/18 06:00
PHST- 2019/03/18 06:00 [pubmed]
PHST- 2019/03/18 06:01 [medline]
PHST- 2019/03/18 06:00 [entrez]
PHST- 2019/03/14 00:00 [pmc-release]
AID - S2213-1582(19)30084-1 [pii]
AID - 101734 [pii]
AID - 10.1016/j.nicl.2019.101734 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2019;22:101734. doi: 10.1016/j.nicl.2019.101734. Epub 2019 Mar 
      14.