PMID- 30878415 OWN - NLM STAT- MEDLINE DCOM- 20200819 LR - 20200819 IS - 1876-7591 (Electronic) IS - 1876-7591 (Linking) VI - 12 IP - 11 Pt 1 DP - 2019 Nov TI - Meta-Analysis of the Prognostic Role of Late Gadolinium Enhancement and Global Systolic Impairment in Left Ventricular Noncompaction. PG - 2141-2151 LID - S1936-878X(19)30156-1 [pii] LID - 10.1016/j.jcmg.2018.12.029 [doi] AB - OBJECTIVES: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC). BACKGROUND: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear. METHODS: A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed. RESULTS: Four studies with 574 patients with LVNC and 677 with no LVNC and an average follow-up duration of 5.2 years were analyzed. In patients with LVNC, LGE was associated with the combined endpoint (pooled odds ratio: 4.9; 95% confidence interval: 1.63 to 14.6; p = 0.005) and cardiac death (pooled odds ratio: 9.8; 95% confidence interval: 2.44 to 39.5; p < 0.001). Preserved left ventricular systolic function was found in 183 patients with LVNC: 25 with positive LGE and 158 with negative LGE. In LVNC with preserved ejection fraction, positive LGE was associated with hard cardiac events (odds ratio: 6.1; 95% confidence interval: 2.1 to 17.5; p < 0.001). No hard cardiac events were recorded in patients with LVNC, preserved ejection fraction, and negative LGE. CONCLUSIONS: Patients with LVNC but without LGE have a better prognosis than those with LGE. When LGE is negative and global systolic function is preserved, no hard cardiac events are to be expected. Currently available criteria allow diagnosis of LVNC, but to further define the presence and prognostic significance of the disease, LGE and/or global systolic impairment must be considered for better risk stratification. CI - Copyright (c) 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Grigoratos, Chrysanthos AU - Grigoratos C AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy; Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. FAU - Barison, Andrea AU - Barison A AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy. FAU - Ivanov, Alexander AU - Ivanov A AD - Department of Cardiology, New York Methodist Hospital, Brooklyn, New York. FAU - Andreini, Daniele AU - Andreini D AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. FAU - Amzulescu, Mihaela-Silvia AU - Amzulescu MS AD - Division of Cardiology, Department of Cardiovascular Diseases Cliniques St. Luc and Pole de Recherche Cardiovasculaire, Institut de Recherche Experimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium. FAU - Mazurkiewicz, Lukasz AU - Mazurkiewicz L AD - Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland; CMR Unit, Institute of Cardiology, Warsaw, Poland. FAU - De Luca, Antonio AU - De Luca A AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy. FAU - Grzybowski, Jacek AU - Grzybowski J AD - Department of Cardiomyopathies, Institute of Cardiology, Warsaw, Poland. FAU - Masci, Pier Giorgio AU - Masci PG AD - Division of Cardiology and CMR-Center, University Hospital Lausanne, Lausanne, Switzerland. FAU - Marczak, Magdalena AU - Marczak M AD - CMR Unit, Institute of Cardiology, Warsaw, Poland. FAU - Heitner, John F AU - Heitner JF AD - Department of Cardiology, New York Methodist Hospital, Brooklyn, New York. FAU - Schwitter, Juerg AU - Schwitter J AD - Division of Cardiology and CMR-Center, University Hospital Lausanne, Lausanne, Switzerland. FAU - Gerber, Bernhard L AU - Gerber BL AD - Division of Cardiology, Department of Cardiovascular Diseases Cliniques St. Luc and Pole de Recherche Cardiovasculaire, Institut de Recherche Experimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium. FAU - Emdin, Michele AU - Emdin M AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy; Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. FAU - Aquaro, Giovanni Donato AU - Aquaro GD AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy. Electronic address: aquaro@ftgm.it. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20190313 PL - United States TA - JACC Cardiovasc Imaging JT - JACC. Cardiovascular imaging JID - 101467978 RN - 0 (Contrast Media) SB - IM CIN - JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 1):2152-2154. PMID: 31005523 MH - Adult MH - Contrast Media/*administration & dosage MH - Female MH - Fibrosis MH - Humans MH - Isolated Noncompaction of the Ventricular Myocardium/*diagnostic imaging/mortality/physiopathology/therapy MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Predictive Value of Tests MH - Prognosis MH - Risk Assessment MH - Risk Factors MH - Time Factors MH - Ventricular Dysfunction, Left/*diagnostic imaging/mortality/physiopathology/therapy MH - *Ventricular Function, Left MH - *Ventricular Remodeling OTO - NOTNLM OT - hypertrabeculation OT - late gadolinium enhancement OT - left ventricular noncompaction OT - prognosis OT - systolic impairment EDAT- 2019/03/18 06:00 MHDA- 2020/08/20 06:00 CRDT- 2019/03/18 06:00 PHST- 2018/09/21 00:00 [received] PHST- 2018/12/18 00:00 [revised] PHST- 2018/12/20 00:00 [accepted] PHST- 2019/03/18 06:00 [pubmed] PHST- 2020/08/20 06:00 [medline] PHST- 2019/03/18 06:00 [entrez] AID - S1936-878X(19)30156-1 [pii] AID - 10.1016/j.jcmg.2018.12.029 [doi] PST - ppublish SO - JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 1):2141-2151. doi: 10.1016/j.jcmg.2018.12.029. Epub 2019 Mar 13.