PMID- 30879735 OWN - NLM STAT- MEDLINE DCOM- 20210813 LR - 20210813 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 39 IP - 2 DP - 2020 Feb TI - Effect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity. PG - 475-483 LID - S0261-5614(19)30079-2 [pii] LID - 10.1016/j.clnu.2019.02.025 [doi] AB - BACKGROUND & AIMS: The quality of carbohydrates has an essential role in nutritional management of type 2 diabetes mellitus (T2DM) because of its substantial impact on glucose homeostasis. Alcohol-free beer has beneficial bioactive components but it has a relatively high glycemic-index so its consumption is restricted in diabetic subjects. We aimed to explore the effect of an alcohol-free beer with modified carbohydrate composition almost completely eliminating maltose and adding isomaltulose (16.5 g/day) and a resistant maltodextrin (5.28 g/day) in comparison to a regular alcohol-free beer on glycemic control of diabetic subjects with overweight or obesity. DESIGN: We randomized 41 subjects into two groups: a) consumption of 66 cL/day of; regular alcohol-free beer for the first 10 weeks and 66 cL/day of alcohol-free beer with modified carbohydrate composition for the next 10 weeks; b) the same described intervention in opposite order. There was a washout period for 6-8 weeks between the two interventions. Participants were counseled to adhere to a healthy diet for cardiovascular health and to increase physical activity. Clinical, biochemical, anthropometric, lifestyle and satiety assessments were performed at the beginning and at the end of each period. RESULTS: Subjects showed significantly weight loss after the two ten weeks periods (-1.69 +/- 3.21% and -1.77 +/- 3.70% after experimental and regular alcohol-free beers, respectively, P = 0.881). Glucose and glycated hemoglobin did not significantly change after any period. Insulin concentrations and HOMA-IR significantly decreased (-11.1 [-21.3-4.64]% and -1.92 +/- 32.8% respectively) after the intake of experimental alcohol-free beer but not after regular alcohol-free beer. Reductions remained statistically significant after adjusting for weight loss, energy intake, physical activity and intervention order. Subjects reported higher satiety scores after consuming experimental alcohol-free beer. CONCLUSIONS: An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of a resistant maltodextrin within meals led to an improvement in insulin resistance in subjects with T2DM and overweight or obesity. CLINICAL TRIAL REGISTRATION: The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT03337828). CI - Copyright (c) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. FAU - Mateo-Gallego, Rocio AU - Mateo-Gallego R AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain; Universidad de Zaragoza, Zaragoza, Spain. FAU - Perez-Calahorra, Sofia AU - Perez-Calahorra S AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain. FAU - Lamiquiz-Moneo, Itziar AU - Lamiquiz-Moneo I AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain. Electronic address: itziarlamiquiz@gmail.com. FAU - Marco-Benedi, Victoria AU - Marco-Benedi V AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain. FAU - Bea, Ana M AU - Bea AM AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain. FAU - Fumanal, Antonio J AU - Fumanal AJ AD - Grupo Agora - La Zaragozana S.A., Zaragoza, Spain. FAU - Prieto-Martin, Ascension AU - Prieto-Martin A AD - Grupo Agora - La Zaragozana S.A., Zaragoza, Spain. FAU - Laclaustra, Martin AU - Laclaustra M AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain; Fundacion Aragon Investigacion y Desarrollo (ARAID), Zaragoza, Spain. FAU - Cenarro, Ana AU - Cenarro A AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain. FAU - Civeira, Fernando AU - Civeira F AD - Hospital Universitario Miguel Servet, Instituto de Investigacion Sanitaria Aragon (IIS Aragon), CIBERCV, Zaragoza, Spain; Universidad de Zaragoza, Zaragoza, Spain. LA - eng SI - ClinicalTrials.gov/NCT03337828 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20190305 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Dextrins) RN - 67I334IX2M (Isomaltose) RN - V59P50X4UY (isomaltulose) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Beer MH - Dextrins/*blood/pharmacology MH - Diabetes Mellitus, Type 2/*blood/complications MH - Double-Blind Method MH - Female MH - Humans MH - *Insulin Resistance MH - Isomaltose/*analogs & derivatives/blood/pharmacology MH - Male MH - Middle Aged MH - Obesity/blood/complications MH - Overweight/*blood/complications MH - Young Adult OTO - NOTNLM OT - Alcohol-free beer OT - Insulin resistance OT - Isomaltulose OT - Obesity OT - Resistant dextrin OT - Type 2 diabetes EDAT- 2019/03/19 06:00 MHDA- 2021/08/14 06:00 CRDT- 2019/03/19 06:00 PHST- 2018/08/13 00:00 [received] PHST- 2018/11/09 00:00 [revised] PHST- 2019/02/16 00:00 [accepted] PHST- 2019/03/19 06:00 [pubmed] PHST- 2021/08/14 06:00 [medline] PHST- 2019/03/19 06:00 [entrez] AID - S0261-5614(19)30079-2 [pii] AID - 10.1016/j.clnu.2019.02.025 [doi] PST - ppublish SO - Clin Nutr. 2020 Feb;39(2):475-483. doi: 10.1016/j.clnu.2019.02.025. Epub 2019 Mar 5.