PMID- 30880109
OWN - NLM
STAT- MEDLINE
DCOM- 20200304
LR  - 20200304
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 126
IP  - 8
DP  - 2019 Aug
TI  - Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: 
      Toddler Aphakia and Pseudophakia Study (TAPS).
PG  - 1189-1195
LID - S0161-6420(18)33071-9 [pii]
LID - 10.1016/j.ophtha.2019.03.011 [doi]
AB  - PURPOSE: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 
      months of age. DESIGN: Retrospective case series at 10 Infant Aphakia Treatment 
      Study (IATS) sites. PARTICIPANTS: The Toddler Aphakia and Pseudophakia Study is a 
      registry of children treated by surgeons who participated in the IATS. METHODS: 
      Children underwent unilateral cataract surgery with or without intraocular lens 
      (IOL) placement during the IATS enrollment years of 2004 and 2010. MAIN OUTCOME 
      MEASURES: Intraoperative complications, adverse events (AEs), visual acuity, and 
      strabismus. RESULTS: Fifty-six children were included with a mean postoperative 
      follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 
      7.2-22.9). Ninety-two percent received a primary IOL. Intraoperative 
      complications occurred in 4 patients (7%). At 5 years of age, visual acuity of 
      treated eyes was very good (>/=20/40) in 11% and poor (</=20/200) in 44%. Adverse 
      events were identified in 24%, with a 4% incidence of glaucoma suspect. An 
      additional unplanned intraocular surgery occurred in 14% of children. Neither AEs 
      nor intraocular reoperations were more common for children with surgery at 7 to 
      12 months of age than for those who underwent surgery at 13 to 24 months of age 
      (AE rate, 21% vs. 25% [P = 0.60]; reoperation rate, 13% vs. 16% [P = 1.00]). 
      CONCLUSIONS: Although most children underwent IOL implantation concurrent with 
      unilateral cataract removal, the incidence of complications, reoperations, and 
      glaucoma was low when surgery was performed between 7 and 24 months of age and 
      compared favorably with same-site IATS data for infants undergoing surgery before 
      7 months of age. Our study showed that IOL implantation is relatively safe in 
      children older than 6 months and younger than 2 years.
CI  - Copyright (c) 2019 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Bothun, Erick D
AU  - Bothun ED
AD  - Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; Department of 
      Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, 
      Minnesota. Electronic address: Bothun.Erick@mayo.edu.
FAU - Wilson, M Edward
AU  - Wilson ME
AD  - Storm Eye Institute, Medical University of South Carolina, Charleston, South 
      Carolina.
FAU - Traboulsi, Elias I
AU  - Traboulsi EI
AD  - Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Diehl, Nancy N
AU  - Diehl NN
AD  - Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
FAU - Plager, David A
AU  - Plager DA
AD  - Indiana University School of Medicine, Indianapolis, Indiana.
FAU - Vanderveen, Deborah K
AU  - Vanderveen DK
AD  - Harvard University, Boston, Massachusetts.
FAU - Freedman, Sharon F
AU  - Freedman SF
AD  - Departments of Ophthalmology and Pediatrics, Duke University School of Medicine, 
      Durham, North Carlina.
FAU - Yen, Kimberly G
AU  - Yen KG
AD  - Departments of Ophthalmology and Pediatrics, Baylor College of Medicine and Texas 
      Children's Hospital, Houston, Texas.
FAU - Weil, Natalie C
AU  - Weil NC
AD  - Department of Ophthalmology, Emory University School of Medicine, Atlanta, 
      Georgia.
FAU - Loh, Allison R
AU  - Loh AR
AD  - Department of Ophthalmology, Oregon Health and Science University, Portland, 
      Oregon.
FAU - Morrison, David
AU  - Morrison D
AD  - Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical 
      Center, Nashville, Tennessee.
FAU - Anderson, Jill S
AU  - Anderson JS
AD  - Department of Ophthalmology and Visual Neurosciences, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Lambert, Scott R
AU  - Lambert SR
AD  - Department of Ophthalmology, Emory University School of Medicine, Atlanta, 
      Georgia; Departments of Ophthalmology and Pediatrics, Stanford University Medical 
      Center, Palo Alto, California.
CN  - Toddler Aphakia and Pseudophakia Study Group (TAPS)
LA  - eng
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190314
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aphakia, Postcataract/*surgery
MH  - Cataract/*complications
MH  - Cataract Extraction/*adverse effects
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Intraoperative Complications/epidemiology
MH  - Lens Implantation, Intraocular/*adverse effects
MH  - Male
MH  - Postoperative Complications/epidemiology
MH  - Pseudophakia/*complications
MH  - Retrospective Studies
MH  - Visual Acuity
FIR - Lambert, Scott
IR  - Lambert S
FIR - Hutchinson, Amy
IR  - Hutchinson A
FIR - Christiansen, Stephen
IR  - Christiansen S
FIR - Bothun, Erick
IR  - Bothun E
FIR - Wilson, Ed
IR  - Wilson E
FIR - Traboulsi, Elias
IR  - Traboulsi E
FIR - Plager, David
IR  - Plager D
FIR - Neely, Daniel
IR  - Neely D
FIR - Vanderveen, Deborah
IR  - Vanderveen D
FIR - Buckley, Ed
IR  - Buckley E
FIR - Freedman, Sharon
IR  - Freedman S
FIR - Wallace, David
IR  - Wallace D
FIR - Yen, Kimberly
IR  - Yen K
FIR - Wheeler, David
IR  - Wheeler D
FIR - Morrison, David
IR  - Morrison D
EDAT- 2019/03/19 06:00
MHDA- 2020/03/05 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/11/20 00:00 [received]
PHST- 2019/02/28 00:00 [revised]
PHST- 2019/03/08 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2020/03/05 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - S0161-6420(18)33071-9 [pii]
AID - 10.1016/j.ophtha.2019.03.011 [doi]
PST - ppublish
SO  - Ophthalmology. 2019 Aug;126(8):1189-1195. doi: 10.1016/j.ophtha.2019.03.011. Epub 
      2019 Mar 14.