PMID- 30880161
OWN - NLM
STAT- MEDLINE
DCOM- 20191029
LR  - 20191029
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 703
DP  - 2019 Jun 11
TI  - 7,8-Dihydroxyflavone potentiates ongoing epileptiform activity in mice brain 
      slices.
PG  - 25-31
LID - S0304-3940(19)30168-5 [pii]
LID - 10.1016/j.neulet.2019.03.013 [doi]
AB  - In the central nervous system, Tropomyosin-receptor-kinase B (TrkB) signaling is 
      involved in neuronal survival, differentiation as well as in regulation of 
      synaptic transmission and excitability. As its powerful potential to modulate 
      neuronal functions, TrkB pathway is an attractive target for novel drugs and 
      treatment of common neurological disorders. 7,8-Dihydroxyflavone (DHF), a TrkB 
      receptor agonist, has similar properties with neurotrophin Brain Derived 
      Neurotropic Factor (BDNF). DHF is reported to have a number of beneficial effects 
      in neuroprotection, against depression and improving learning and memory. 
      However, the outcome of acute application of DHF on the excitability of neuronal 
      circuits is not clear. Especially the effects of DHF on synchronized epileptiform 
      activity are not known. In this study, we investigated whether DHF induces 
      epileptiform activity in brain slices and DHF has any effect on already initiated 
      epileptiform discharges. We used acute horizontal hippocampal-entorhinal cortex 
      slices obtained from 30 to 35 days of mice. Extracellular field potential 
      recordings were obtained from entorhinal cortex (EC) and hippocampus CA1 region. 
      DHF did not initiate any epileptiform activity or abnormal discharges. However, 
      DHF increased the frequency of 4 aminopyridine (4AP) induced ictal and interictal 
      events in both EC and CA1. The duration of induced ictal charges were also 
      prolonged upon DHF application. In a number of slices, both EC and CA1, DHF led 
      to ictogenesis. These results suggest that the acute activation of TrkB by DHF 
      has a powerful potential on synchronized neuronal discharges which should be 
      considered in future therapeutical approaches.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Aydin-Abidin, Selcen
AU  - Aydin-Abidin S
AD  - Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 
      Trabzon, Turkey. Electronic address: sabidin@ktu.edu.tr.
FAU - Abidin, Ismail
AU  - Abidin I
AD  - Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 
      Trabzon, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190314
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (7,8-dihydroxyflavanone)
RN  - 0 (Flavanones)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - CA1 Region, Hippocampal/*drug effects/physiopathology
MH  - Entorhinal Cortex/*drug effects/physiopathology
MH  - Epilepsy/*physiopathology
MH  - Female
MH  - Flavanones/*pharmacology
MH  - In Vitro Techniques
MH  - Male
MH  - Membrane Glycoproteins/*agonists
MH  - Mice
MH  - Neurons/drug effects/physiology
MH  - Protein-Tyrosine Kinases
OTO - NOTNLM
OT  - 7,8-Dihydroxyflavone
OT  - Brain slice
OT  - Epileptiform activity
OT  - Mice
OT  - TrkB receptor
EDAT- 2019/03/19 06:00
MHDA- 2019/10/30 06:00
CRDT- 2019/03/19 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/02/22 00:00 [revised]
PHST- 2019/03/09 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/10/30 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - S0304-3940(19)30168-5 [pii]
AID - 10.1016/j.neulet.2019.03.013 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jun 11;703:25-31. doi: 10.1016/j.neulet.2019.03.013. Epub 
      2019 Mar 14.