PMID- 30880926
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20231006
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 14
DP  - 2019
TI  - Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese 
      men over the age of 50 years.
PG  - 445-451
LID - 10.2147/CIA.S164021 [doi]
AB  - AIM: The aim of this study was to determine the relationship between abnormal 
      glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 
      years. PATIENTS AND METHODS: A cross-sectional study of 775 male patients aged 
      over 50 years was performed at our hospital in 2011. The patients were divided 
      into a normal glucose metabolism group, an impaired glucose regulation (IGR) 
      group, and a type 2 diabetes mellitus (T2DM) group. Differences in their bone 
      mineral densities (BMDs), OP detection rates, and indices of bone metabolism were 
      assessed. RESULTS: After adjusting for age and body mass index (BMI), there were 
      no significant differences in lumbar spine, femoral neck, and total hip BMD 
      values in the three groups (P>0.05) nor in OP detection rates (P=0.19). However, 
      there were some significant differences in bone metabolism markers between the 
      groups after adjusting for age, BMI, and serum creatinine (Cr): 25-hydroxyvitamin 
      D (25(OH)D) was positively correlated with the presence of abnormal 
      glycometabolism (r=0.08; P<0.01), while beta-carboxy-terminal cross-linking 
      telopeptide of type I collagen (beta-CTX), bone gamma-carboxyglutamic acid protein 
      (BGP; osteocalcin [OC]), and procollagen type 1 intact N-terminal propeptide 
      (P1NP) were negatively correlated (r=-0.13, -0.21, -0.14, respectively; P<0.01). 
      Logistic regression analysis of the data indicated that BGP was the only bone 
      metabolism marker significantly influenced by abnormal glucose metabolism (OR 
      =0.96). CONCLUSION: There were no significant differences in BMD or OP detection 
      rates between the three glycometabolism groups after adjusting for age and BMI. 
      However, the bone metabolism marker, BGP, was significantly negatively correlated 
      with abnormal glucose metabolism.
FAU - Liu, Minyan
AU  - Liu M
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Lu, Yanhui
AU  - Lu Y
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Cheng, Xiaoling
AU  - Cheng X
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Ma, Lichao
AU  - Ma L
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Miao, Xinyu
AU  - Miao X
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Li, Nan
AU  - Li N
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Sun, Boruo
AU  - Sun B
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Yan, Shuangtong
AU  - Yan S
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Li, Jian
AU  - Li J
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
FAU - Li, Chunling
AU  - Li C
AD  - Department of Elderly Endocrinology, Chinese PLA General Hospital, Haidian 
      District, Beijing 100853, China, lclin301@126.com.
LA  - eng
GR  - R01 AA022301/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20190225
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (Collagen Type I)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 0 (Procollagen)
RN  - 0 (collagen type I trimeric cross-linked peptide)
RN  - 0 (procollagen Type I N-terminal peptide)
RN  - 104982-03-8 (Osteocalcin)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Bone Density
MH  - China
MH  - Collagen Type I/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Femur Neck/diagnostic imaging
MH  - Glucose/*metabolism
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/blood
MH  - Osteoporosis/*blood/complications/*diagnostic imaging
MH  - Peptide Fragments/blood
MH  - Peptides/blood
MH  - Procollagen/blood
MH  - Vitamin D/analogs & derivatives/blood
PMC - PMC6394237
OTO - NOTNLM
OT  - bone mineral density
OT  - bone turnover markers
OT  - diabetes mellitus
OT  - osteoporosis
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2019/03/19 06:00
MHDA- 2019/04/30 06:00
PMCR- 2019/02/25
CRDT- 2019/03/19 06:00
PHST- 2019/03/19 06:00 [entrez]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2019/02/25 00:00 [pmc-release]
AID - cia-14-445 [pii]
AID - 10.2147/CIA.S164021 [doi]
PST - epublish
SO  - Clin Interv Aging. 2019 Feb 25;14:445-451. doi: 10.2147/CIA.S164021. eCollection 
      2019.