PMID- 30881443
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20200309
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2019
DP  - 2019
TI  - Cortical and Subcortical Contributions to Neuroplasticity after Repetitive 
      Transspinal Stimulation in Humans.
PG  - 4750768
LID - 10.1155/2019/4750768 [doi]
LID - 4750768
AB  - The objectives of this study were to establish cortical and subcortical 
      contributions to neuroplasticity induced by noninvasive repetitive transspinal 
      stimulation in human subjects free of any neurological disorder. To meet our 
      objectives, before and after 40 minutes of transspinal stimulation we established 
      changes in tibialis anterior (TA) motor-evoked potentials (MEPs) in response to 
      paired transcranial magnetic stimulation (TMS) pulses at interstimulus intervals 
      (ISIs) consistent with I-wave periodicity. In order to establish to what extent 
      similar actions are exerted at the spinal cord and motor axons, changes in soleus 
      H-reflex and transspinal evoked potential (TEP) amplitude following transspinal 
      and group Ia afferent conditioning stimulation, respectively, were established. 
      After 40 min of transspinal stimulation, the TA MEP consecutive peaks of 
      facilitation produced by paired TMS pulses were significantly decreased 
      supporting for depression of I-waves. Additionally, the soleus H-reflex and ankle 
      TEP depression following transspinal and group Ia afferent conditioning 
      stimulation was potentiated at intervals when both responses interacted at the 
      spinal cord and nerve axons. These findings support the notion that repetitive 
      transspinal stimulation decreases corticocortical inputs onto corticospinal 
      neurons and promotes a surround inhibition in the spinal cord and nerve axons. 
      This novel method may be a suitable neuromodulation tool to alter excitability at 
      cortical and subcortical levels in neurological disorders.
FAU - Murray, Lynda M
AU  - Murray LM
AD  - Klab4Recovery Research Laboratory, Department of Physical Therapy, College of 
      Staten Island, New York, NY 10314, USA.
FAU - Islam, Md Anamul
AU  - Islam MA
AD  - Klab4Recovery Research Laboratory, Department of Physical Therapy, College of 
      Staten Island, New York, NY 10314, USA.
FAU - Knikou, Maria
AU  - Knikou M
AUID- ORCID: 0000-0002-6277-236X
AD  - Klab4Recovery Research Laboratory, Department of Physical Therapy, College of 
      Staten Island, New York, NY 10314, USA.
AD  - PhD Program in Biology and Collaborative Neuroscience Program, Graduate Center of 
      The City University of New York, New York, NY 10016, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190207
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*physiology
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - Spinal Cord/*physiology
MH  - Young Adult
PMC - PMC6383395
EDAT- 2019/03/19 06:00
MHDA- 2019/05/14 06:00
PMCR- 2019/02/07
CRDT- 2019/03/19 06:00
PHST- 2018/08/23 00:00 [received]
PHST- 2018/10/26 00:00 [revised]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2019/03/19 06:00 [entrez]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
PHST- 2019/02/07 00:00 [pmc-release]
AID - 10.1155/2019/4750768 [doi]
PST - epublish
SO  - Neural Plast. 2019 Feb 7;2019:4750768. doi: 10.1155/2019/4750768. eCollection 
      2019.