PMID- 30881503
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 17
IP  - 4
DP  - 2019 Apr
TI  - p53 overexpression is a prognosticator of poor outcome in esophageal cancer.
PG  - 3826-3834
LID - 10.3892/ol.2019.10020 [doi]
AB  - Immunohistochemistry studies on p53 inactivation in esophageal cancer are 
      available with inconclusive results. Data on the combined effect of p53 protein 
      accumulation and TP53 genomic deactivation in large scale studies for esophageal 
      cancer are currently lacking. A tissue microarray with 691 esophageal cancer 
      samples was analyzed by p53 immunohistochemistry and fluorescence in situ 
      hybridization (FISH). Nuclear p53 accumulation was observed in 45.9% of patients 
      with adenocarcinoma (AC) and in 40.0% in squamous cell carcinoma (SCC). 
      Heterozygous TP53 deletions occurred in 40.9% in AC and in 19.4% in SCC. 
      Homozygous deletions did not occur at all. High-level p53 immunostaining was 
      associated with shortened overall survival in AC and SCC while TP53 deletions 
      alone showed no correlation with survival. High-level p53 immunostaining in 
      patients with AC was associated with advanced tumor (P=0.019) and Union for 
      International Cancer Control stages (P=0.004), grading (P=0.027) and the 
      resection margin status (P=0.006). Associations between p53 immunostaining and 
      SCC were not found. TP53 deletions were found to be associated with advanced 
      tumor stages (P=0.028) and the presence of lymph node metastasis (P=0.009) in 
      SCC. In conclusion, strong p53 immunostaining, but not TP53 deletion alone, is 
      associated with unfavorable outcomes and may therefore represent a clinically 
      useful molecular marker in esophageal cancer.
FAU - Melling, Nathaniel
AU  - Melling N
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center 
      Hamburg-Eppendorf, D-20246 Hamburg, Germany.
FAU - Norrenbrock, Sonja
AU  - Norrenbrock S
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Kluth, Martina
AU  - Kluth M
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Simon, Ronald
AU  - Simon R
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Hube-Magg, Claudia
AU  - Hube-Magg C
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Steurer, Stefan
AU  - Steurer S
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Hinsch, Andrea
AU  - Hinsch A
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Burandt, Eike
AU  - Burandt E
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Jacobsen, Frank
AU  - Jacobsen F
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Wilczak, Waldemar
AU  - Wilczak W
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Quaas, Alexander
AU  - Quaas A
AD  - Institute for Pathology, University Hospital Cologne, D-50937 Cologne, Germany.
FAU - Bockhorn, Maximillian
AU  - Bockhorn M
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center 
      Hamburg-Eppendorf, D-20246 Hamburg, Germany.
FAU - Grupp, Katharina
AU  - Grupp K
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center 
      Hamburg-Eppendorf, D-20246 Hamburg, Germany.
FAU - Tachezy, Michael
AU  - Tachezy M
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center 
      Hamburg-Eppendorf, D-20246 Hamburg, Germany.
FAU - Izbicki, Jakob
AU  - Izbicki J
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center 
      Hamburg-Eppendorf, D-20246 Hamburg, Germany.
FAU - Sauter, Guido
AU  - Sauter G
AD  - Institute for Pathology, University Medical Center Hamburg-Eppendorf, D-20246 
      Hamburg, Germany.
FAU - Gebauer, Florian
AU  - Gebauer F
AD  - Department of Surgery, University Hospital Cologne, D-50937 Cologne, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190206
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6403495
OTO - NOTNLM
OT  - esophageal cancer
OT  - outcome
OT  - p53 expression
EDAT- 2019/03/19 06:00
MHDA- 2019/03/19 06:01
PMCR- 2019/02/06
CRDT- 2019/03/19 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/03/19 06:00 [entrez]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/03/19 06:01 [medline]
PHST- 2019/02/06 00:00 [pmc-release]
AID - OL-0-0-10020 [pii]
AID - 10.3892/ol.2019.10020 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 Apr;17(4):3826-3834. doi: 10.3892/ol.2019.10020. Epub 2019 Feb 
      6.