PMID- 30882147
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20201218
IS  - 1465-3621 (Electronic)
IS  - 0368-2811 (Linking)
VI  - 49
IP  - 6
DP  - 2019 Jun 1
TI  - Cryobiopsy during flex-rigid pleuroscopy: an emerging alternative biopsy method 
      in malignant pleural mesothelioma. A comparative study of pathology.
PG  - 559-566
LID - 10.1093/jjco/hyz032 [doi]
AB  - BACKGROUND: Malignant pleural mesothelioma (MPM) is rarely an asbestos-related 
      cancer with a poor prognosis that is difficult to distinguish from some benign 
      conditions by using conventional biopsy techniques. The purpose of this study was 
      to evaluate the utility of a novel biopsy technique using a cryoprobe during 
      flex-rigid pleuroscopy for diagnosing MPM. METHODS: Consecutive patients who 
      underwent pleural cryobiopsy during flex-rigid pleuroscopy from June through 
      November 2017 to diagnose the cause of pleural effusion were collected. From 
      these, cases ultimately diagnosed as MPM were selected. Pleural biopsies were 
      performed by using conventional instruments followed by a cryoprobe. The obtained 
      samples were histologically examined and compared with regard to the quality 
      (sample size, tissue depth, and crush rate), immunohistochemical (IHC) staining, 
      and p16 by fluorescence in situ hybridization (FISH). RESULTS: In total, five 
      patients ultimately diagnosed as MPM were enrolled. The sample collected was 
      significantly larger for cryobiopsy than conventional biopsy (18.9 mm2 vs. 6.7 
      mm2, P < 0.001). Full-thickness biopsies were achieved in four cases by using 
      cryobiopsy compared with one case by conventional biopsy. Moreover, the crush 
      rate was significantly less for cryobiopsy than conventional biopsy (9% vs. 35%, 
      P < 0.001). The results of IHC staining and p16 by FISH were similar between 
      biopsy techniques. Cryobiopsy successfully led to accurate diagnosis of MPM in 
      all cases, whereas conventional biopsy was diagnostic in one case. No severe 
      complications developed after either biopsy technique. CONCLUSION: Cryobiopsy 
      during flex-rigid pleuroscopy is a feasible and convenient biopsy technique that 
      supports precise diagnosis of MPM.
CI  - (c) The Author(s) 2019. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Nakai, Toshiyuki
AU  - Nakai T
AD  - Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center 
      Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
FAU - Matsumoto, Yuji
AU  - Matsumoto Y
AD  - Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center 
      Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
AD  - Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, 
      Chuo-ku, Tokyo, Japan.
FAU - Sasada, Shinji
AU  - Sasada S
AD  - Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center 
      Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
AD  - Department of Respiratory Medicine, Tokyo Saiseikai Central Hospital, 1-4-17 
      Mita, Minato-ku, Tokyo, Japan.
FAU - Tanaka, Midori
AU  - Tanaka M
AD  - Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center 
      Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
FAU - Tsuchida, Takaaki
AU  - Tsuchida T
AD  - Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center 
      Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
FAU - Ohe, Yuichiro
AU  - Ohe Y
AD  - Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, 
      Chuo-ku, Tokyo, Japan.
FAU - Motoi, Noriko
AU  - Motoi N
AD  - Department of Pathology and Clinical Laboratories, Pathology Division, National 
      Cancer Center Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
SB  - IM
MH  - Aged
MH  - Biopsy/instrumentation/methods
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnosis
MH  - Male
MH  - Mesothelioma/*diagnosis
MH  - Mesothelioma, Malignant
MH  - Middle Aged
MH  - Pleural Neoplasms/*diagnosis
MH  - Thoracoscopy/*instrumentation/*methods
OTO - NOTNLM
OT  - Malignant pleural mesothelioma
OT  - cryobiopsy
OT  - flex-rigid pleuroscopy
OT  - full-thickness pleural biopsy
EDAT- 2019/03/19 06:00
MHDA- 2019/07/17 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/05/03 00:00 [received]
PHST- 2018/12/12 00:00 [revised]
PHST- 2019/02/22 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 5382377 [pii]
AID - 10.1093/jjco/hyz032 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 2019 Jun 1;49(6):559-566. doi: 10.1093/jjco/hyz032.