PMID- 30882233
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 13
IP  - 4
DP  - 2019 Mar
TI  - Loss of the tRNA(Lys)(CUU) encoding gene, Chr-11 tRNA-Lys-CUU, is not associated 
      with Type 2 diabetes mellitus.
PG  - 259-266
LID - 10.2217/bmm-2018-0322 [doi]
AB  - AIM: To investigate the presence/absence of the Chr-11 tRNA-Lys-CUU gene as a 
      marker for genetic predisposition to Type 2 diabetes mellitus (T2DM). METHODS: We 
      enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We 
      evaluated clinical and biochemical parameters (body mass index, hypertension, 
      cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed 
      a genotypic profiling of Chr-11 tRNA-Lys-CUU by polymerase chain reaction 
      analyses. RESULTS: Approximately one third of the population lacked Chr-11 
      tRNA-Lys-CUU. We did not observe a statistically significant association between 
      the presence/absence of Chr-11 tRNA-Lys-CUU and T2DM. CONCLUSION: The genotypic 
      distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that 
      reported by others. This gene failed as a marker for T2DM predisposition.
FAU - Yang, Pablo
AU  - Yang P
AD  - Catedra de Biotecnologia, Facultad de Ciencias Quimicas, Unidad Asociada al 
      CONICET: Area de Cs. Agrarias, Ingenieria, Cs. Biologicas, Universidad Catolica 
      de Cordoba, Cordoba, Argentina.
FAU - Beltramo, Dante Miguel
AU  - Beltramo DM
AD  - Catedra de Biotecnologia, Facultad de Ciencias Quimicas, Unidad Asociada al 
      CONICET: Area de Cs. Agrarias, Ingenieria, Cs. Biologicas, Universidad Catolica 
      de Cordoba, Cordoba, Argentina.
FAU - de Pouplana, Lluis Ribas
AU  - de Pouplana LR
AD  - Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of 
      Science & Technology, 08028 Barcelona, Catalonia, Spain.
AD  - Catalan Institution for Research & Advanced Studies (ICREA), 08010 Barcelona, 
      Catalonia, Spain.
FAU - Soria, Nestor Walter
AU  - Soria NW
AD  - Catedra de Biotecnologia, Facultad de Ciencias Quimicas, Unidad Asociada al 
      CONICET: Area de Cs. Agrarias, Ingenieria, Cs. Biologicas, Universidad Catolica 
      de Cordoba, Cordoba, Argentina.
FAU - Torres, Adrian Gabriel
AU  - Torres AG
AD  - Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of 
      Science & Technology, 08028 Barcelona, Catalonia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190318
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Transfer, Lys)
SB  - IM
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - *Gene Deletion
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Transfer, Lys/*genetics
MH  - Spain/epidemiology
OTO - NOTNLM
OT  - PCR
OT  - T2DM
OT  - Type 2 diabetes mellitus
OT  - biomarker
OT  - gene translation
OT  - genotypic profiling
OT  - insulin
OT  - tRNA
OT  - tRNA gene
OT  - tRNA-Lys-CUU
EDAT- 2019/03/19 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/03/19 06:00
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 10.2217/bmm-2018-0322 [doi]
PST - ppublish
SO  - Biomark Med. 2019 Mar;13(4):259-266. doi: 10.2217/bmm-2018-0322. Epub 2019 Mar 
      18.