PMID- 30882257
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20191217
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 139
IP  - 3
DP  - 2019 Mar
TI  - The prognostic value of preoperative derived neutrophil-to-lymphocyte ratio in 
      patients undergoing total laryngectomy with laryngeal carcinoma.
PG  - 294-298
LID - 10.1080/00016489.2019.1566780 [doi]
AB  - BACKGROUND: Emerging evidence indicate that inflammation plays a crucial role in 
      carcinogenesis and tumor progression. Inflammatory response biomarkers are 
      recognized as promising prognostic factors in laryngeal squamous cell carcinoma 
      (LSCC). OBJECTIVE: To evaluate the prognostic significance of preoperative 
      derived neutrophil-to-lymphocyte ratio (dNLR) in patients with total 
      laryngectomy. METHODS: This was a retrospective analysis of 137 patients with 
      LSCC who received total laryngectomy from January 2009 to December 2015. The 
      preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio 
      (PLR), and dNLR were calculated. Receiver-operating characteristic (ROC) curve 
      was used to determine the cut-off values of these parameters. Univariate analysis 
      and multivariate Cox regression model were used to evaluate the association 
      between these parameters and recurrence-free survival (RFS) and overall survival 
      (OS). RESULTS: The optimal critical value of dNLR was 1.85, by which cases were 
      divided into high dNLR group (dNLR >/= 1.85) and low dNLR group (dNLR < 1.85). The 
      elevated dNLR was significantly associated with decreased RFS (HR 2.72, 95% CI 
      1.56-4.75, p = .000) and remained significant in multivariate analysis 
      (p = .034). However, we did not find any significant correlation between dNLR and 
      OS. CONCLUSIONS: An elevated preoperative dNLR may be an independent prognostic 
      biomarker for RFS in patients undergoing total laryngectomy with LSCC.
FAU - Song, Shenghua
AU  - Song S
AD  - a Department of Otorhinolaryngology , The First Affiliated Hospital, Nanjing 
      Medical University , Nanjing , China.
FAU - Chen, Huijun
AU  - Chen H
AD  - a Department of Otorhinolaryngology , The First Affiliated Hospital, Nanjing 
      Medical University , Nanjing , China.
FAU - Dong, Weida
AU  - Dong W
AD  - a Department of Otorhinolaryngology , The First Affiliated Hospital, Nanjing 
      Medical University , Nanjing , China.
FAU - Zhou, Han
AU  - Zhou H
AD  - a Department of Otorhinolaryngology , The First Affiliated Hospital, Nanjing 
      Medical University , Nanjing , China.
LA  - eng
PT  - Journal Article
DEP - 20190318
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*diagnosis/immunology/mortality/surgery
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/immunology/mortality/surgery
MH  - Laryngectomy
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Preoperative Period
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Laryngeal carcinoma
OT  - dNLR
OT  - prognosis
OT  - recurrence-free survival (RFS)
EDAT- 2019/03/19 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/03/19 06:00
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 10.1080/00016489.2019.1566780 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2019 Mar;139(3):294-298. doi: 10.1080/00016489.2019.1566780. 
      Epub 2019 Mar 18.