PMID- 30882700
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 11
DP  - 2019 Mar
TI  - Association of polymorphisms in STRA6 gene with gestational diabetes mellitus in 
      a Chinese Han population.
PG  - e14885
LID - 10.1097/MD.0000000000014885 [doi]
LID - e14885
AB  - Cell and animal experiments have found that in addition to being a retinol 
      transporter, Stimulated by Retinoic Acid 6 (STRA6) also functions as a surface 
      signaling receptor by which retinol regulates insulin responses. Several studies 
      revealed that the STRA6 gene may contribute to the pathogenesis of type 2 
      diabetes mellitus (T2DM). Gestational diabetes mellitus (GDM) and T2DM have some 
      risk factors in common. The present study was directed to investigate whether the 
      3 single nucleotide polymorphism (SNPs) (rs11633768, rs351219, and rs736118) of 
      STRA6 correlate with the development of GDM in Chinese pregnant women. We also 
      aimed to estimate the relationship between SNPs with fasting blood glucose level, 
      1-hour and 2-hour blood glucose levels after 75 g oral glucose intake, fasting 
      insulin and insulin resistance levels to better study the relationship between 
      STRA6 and glucose metabolism.Case-control studies were conducted to compare the 
      GDM and control groups. A total of 334 cases and 367 controls were recruited. 
      Three tagSNPs of STRA6, rs11633768, rs351219, and rs736118, were selected. A 
      chi-square test, logistic regression, and linear regression were used to estimate 
      the relationship between SNPs with GDM risk and oral glucose tolerance test 
      (OGTT), fasting insulin and homeostasis model assessment of insulin resistance 
      (HOMA-IR) levels. Regression analyses were all adjusted by maternal age, 
      pre-pregnancy BMI, and weekly BMI growth. The Bonferroni correction was applied 
      for multiple comparisons.After adjusting the maternal age, pre-pregnancy BMI and 
      weekly BMI growth, STRA6 rs736118 was associated with fasting insulin level 
      (Beta = -1.468, P = .036), and the association between rs736118 and HOMA-IR was 
      of borderline significance (Beta = -0.290, P = .093) under the dominance 
      model.This study found that there is a significant association between STRA6 
      polymorphism and GDM.
FAU - Hu, Shimin
AU  - Hu S
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University.
FAU - Yan, Junxia
AU  - Yan J
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University.
FAU - You, Yiping
AU  - You Y
AD  - Department of Obstetrics and Gynecology.
FAU - Yang, Guilian
AU  - Yang G
AD  - Nutrition Department, Hunan Provincial Hospital of Maternal and Child Health.
FAU - Zhou, Hui
AU  - Zhou H
AD  - The Health Management Department of The Third Xiangya Hospital of Central South 
      University, Changsha, Hunan, PR China.
FAU - Li, Xun
AU  - Li X
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University.
FAU - Liao, Xin
AU  - Liao X
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University.
FAU - Tan, Hongzhuan
AU  - Tan H
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Membrane Proteins)
RN  - 0 (STRA6 protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/ethnology/genetics
MH  - Diabetes, Gestational/ethnology/*genetics
MH  - Female
MH  - Genetic Testing/methods
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Logistic Models
MH  - Membrane Proteins/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Pregnancy
MH  - Risk Factors
PMC - PMC6426506
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/03/19 06:00
MHDA- 2019/04/02 06:00
PMCR- 2019/03/15
CRDT- 2019/03/19 06:00
PHST- 2019/03/19 06:00 [entrez]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2019/03/15 00:00 [pmc-release]
AID - 00005792-201903150-00084 [pii]
AID - MD-D-18-05303 [pii]
AID - 10.1097/MD.0000000000014885 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Mar;98(11):e14885. doi: 10.1097/MD.0000000000014885.