PMID- 30882835
OWN - NLM
STAT- MEDLINE
DCOM- 20190524
LR  - 20190524
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 11
IP  - 13
DP  - 2019 Mar 28
TI  - Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: 
      combination of photothermal ablation and gene therapy against laryngeal squamous 
      cell carcinoma.
PG  - 6285-6296
LID - 10.1039/c9nr01122f [doi]
AB  - Multimodality therapy under imaging-guidance is significant to improve the 
      accuracy of cancer treatment. In this study, a photoacoustic imaging (PAI)-guided 
      anticancer strategy based on poly-l-lysine functionalized melanin nanoparticles 
      (MNP-PLL) was developed to treat laryngeal squamous cell carcinoma (LSCC). As a 
      promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA 
      nanoparticles were combined with photothermal ablation against primary tumors and 
      miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor 
      cells. Furthermore, taking advantage of the photoacoustic properties of melanin, 
      PAI guided therapy could optimize the time point of NIR irradiation to maximize 
      the efficacy of photothermal therapy (PTT). The in vitro and in vivo results 
      proved that the combined treatments displayed the most significant tumor 
      suppression compared with monotherapy. By integrating thermo-gene therapies into 
      a theranostic nanoplatform, the MNP-PLL/miR-145-5p nanoparticles significantly 
      suppressed the LSCC progression, indicating their great potential use for cancer 
      therapy.
FAU - Fan, Bo
AU  - Fan B
AD  - Department of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.
FAU - Yang, Xi
AU  - Yang X
FAU - Li, Xiaoyan
AU  - Li X
FAU - Lv, Shuxin
AU  - Lv S
FAU - Zhang, Huanhu
AU  - Zhang H
FAU - Sun, Jinghua
AU  - Sun J
FAU - Li, Liping
AU  - Li L
FAU - Wang, Lingjie
AU  - Wang L
FAU - Qu, Botao
AU  - Qu B
FAU - Peng, Xiaoyang
AU  - Peng X
FAU - Zhang, Ruiping
AU  - Zhang R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (MIRN145 microRNA, human)
RN  - 0 (Melanins)
RN  - 0 (MicroRNAs)
RN  - 25104-18-1 (Polylysine)
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/diagnostic imaging/pathology/*therapy
MH  - Cell Line, Tumor
MH  - Cell Movement/drug effects/radiation effects
MH  - Cell Survival/drug effects/radiation effects
MH  - Combined Modality Therapy
MH  - *Genetic Therapy
MH  - Humans
MH  - Infrared Rays
MH  - Laryngeal Neoplasms/diagnostic imaging/pathology/*therapy
MH  - Melanins/*chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/chemistry/metabolism
MH  - Microscopy, Confocal
MH  - Nanoparticles/*chemistry/therapeutic use/toxicity
MH  - Phototherapy
MH  - Polylysine/chemistry
MH  - Theranostic Nanomedicine
EDAT- 2019/03/19 06:00
MHDA- 2019/05/28 06:00
CRDT- 2019/03/19 06:00
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/05/28 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 10.1039/c9nr01122f [doi]
PST - ppublish
SO  - Nanoscale. 2019 Mar 28;11(13):6285-6296. doi: 10.1039/c9nr01122f.