PMID- 30883809
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191210
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 59
IP  - 6
DP  - 2019 Jun
TI  - The placebo response in myasthenia gravis assessed by quantitative myasthenia 
      gravis score: A meta-analysis.
PG  - 671-678
LID - 10.1002/mus.26469 [doi]
AB  - INTRODUCTION: This meta-analysis investigates the placebo response in generalized 
      myasthenia gravis (MG) trials by means of Quantitative Myasthenia Gravis (QMG) 
      scores. METHODS: PubMed, Scopus, Web of Science, Cochrane Controlled Trial 
      Register, and EMBASE were searched. QMG score, dropouts rate, adverse events 
      (AEs), and AEs responsible for dropouts were examined, together with treatment 
      moderators. RESULTS: The magnitude of placebo response showed an effect size of 
      0.24, which was significantly lower than 0.67 of the drug response (P = 0.019). 
      Furthermore, the forest plot revealed that, overall, active treatments showed a 
      significantly higher impact on QMG scores than placebos. CONCLUSIONS: Placebo and 
      drug responses in MG trials are small and moderate, respectively. The lack of MG 
      trials with a pure placebo arm or a no-treatment control arm made it impossible 
      to disentangle improvements due to the placebo psychological effect from other 
      effects such as natural history and/or regression to the mean. Muscle Nerve 
      59:671-678, 2019.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Frisaldi, Elisa
AU  - Frisaldi E
AUID- ORCID: 0000-0002-3783-1997
AD  - Department of Neuroscience, University of Turin Medical School, Corso Raffaello 
      30, 10125 Turin, Italy.
FAU - Shaibani, Aziz
AU  - Shaibani A
AD  - Nerve & Muscle Center, Houston, Texas, USA.
FAU - Vollert, Jan
AU  - Vollert J
AD  - Pain Research, Faculty of Medicine, Department of Surgery & Cancer, Imperial 
      College London, London, United Kingdom.
AD  - Center of Biomedicine and Medical Technology Mannheim CBTM, Medical Faculty 
      Mannheim, Heidelberg University, Germany.
FAU - Ferrero, Bruno
AU  - Ferrero B
AD  - Department of Neuroscience, University of Turin Medical School, Corso Raffaello 
      30, 10125 Turin, Italy.
FAU - Carrino, Roberta
AU  - Carrino R
AD  - Department of Neuroscience, University of Turin Medical School, Corso Raffaello 
      30, 10125 Turin, Italy.
FAU - Ibraheem, Hayan Dhamer
AU  - Ibraheem HD
AD  - Nerve & Muscle Center, Houston, Texas, USA.
FAU - Vase, Lene
AU  - Vase L
AD  - Department of Psychology and Behavioural Sciences, School of Business and Social 
      Sciences, Aarhus University, Aarhus, Denmark.
FAU - Benedetti, Fabrizio
AU  - Benedetti F
AD  - Department of Neuroscience, University of Turin Medical School, Corso Raffaello 
      30, 10125 Turin, Italy.
AD  - Plateau Rosa Laboratories, Plateau Rosa, Italy/Switzerland.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20190402
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Humans
MH  - Myasthenia Gravis/*drug therapy/physiopathology
MH  - Outcome Assessment, Health Care
MH  - *Placebo Effect
OTO - NOTNLM
OT  - clinical trials
OT  - meta-analysis
OT  - myasthenia gravis
OT  - neuromuscular disorders
OT  - placebo effect
OT  - placebo response
EDAT- 2019/03/19 06:00
MHDA- 2019/10/24 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/09/01 00:00 [received]
PHST- 2019/03/11 00:00 [revised]
PHST- 2019/03/12 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 10.1002/mus.26469 [doi]
PST - ppublish
SO  - Muscle Nerve. 2019 Jun;59(6):671-678. doi: 10.1002/mus.26469. Epub 2019 Apr 2.