PMID- 30884197
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20200129
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 22
IP  - 7
DP  - 2019 Jul
TI  - Clinical correlates of HLA-B*27 and its subtypes in enthesitis-related arthritis 
      variant of juvenile idiopathic arthritis in south Indian Tamil patients.
PG  - 1289-1296
LID - 10.1111/1756-185X.13551 [doi]
AB  - AIM: The aim of the study was to assess the distribution of human leukocyte 
      antigen (HLA)-B*27 subtypes and its correlation with disease phenotypes in 
      children with enthesitis-related arthritis variant of juvenile idiopathic 
      arthritis (JIA-ERA). METHOD: One hundred and sixty patients (132 males, 28 
      females) satisfying the International League Against Rheumatism (ILAR) 
      classification criteria for JIA-ERA were assessed and relevant demographic, 
      clinical and radiographic data were documented. HLA-B*27 typing was done for all 
      the patients and B*27 positive samples were subjected to high-resolution gene 
      sequencing. The effect of duration of illness, HLA-B*27, its subtypes, and gender 
      on the clinical phenotype were analyzed. RESULTS: The mean age of disease onset 
      was 12.69 +/- 2.4 years with a male:female ratio of 4.7:1.0. HLA-B*27 was positive 
      in 109/160 patients and HLA-B*27:04 was detected in 63% followed by B*27:05 
      (30%). Duration of illness was greater in patients with skeletal deformity, hip 
      arthritis, sacroiliitis, cervical spine involvement and acute anterior uveitis 
      (AAU) (P < 0.05). HLA-B*27 positivity was associated with a prolonged course of 
      disease, higher incidence of AAU (14.7% vs 2%, P = 0.015), family history of 
      spondyloarthritis (21.1% vs 5.9%; P = 0.015) and higher erythrocyte sedimentation 
      rate as compared to HLA-B*27 negative patients (P < 0.01). The HLA-B*27:04 and 
      *27:05 positive patients had similar clinical phenotypes. CONCLUSION: Presence of 
      HLA-B*27 and long duration of illness results in skeletal deformity, hip 
      arthritis, sacroiliitis, cervical spine involvement and AAU. HLA-B*27:04 followed 
      by B*27:05 are the most common HLA-B*27 subtypes in our study population and both 
      have a similar clinical phenotype.
CI  - (c) 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Kavadichanda, Chengappa G
AU  - Kavadichanda CG
AUID- ORCID: 0000-0002-3643-3989
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education & Research, Puducherry, India.
FAU - Seth, Gaurav
AU  - Seth G
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education & Research, Puducherry, India.
FAU - Kumar, Gunjan
AU  - Kumar G
AD  - Department of Preventive and Social Medicine, Jawaharlal Institute of 
      Postgraduate Medical Education & Research, Puducherry, India.
FAU - Gulati, Reena
AU  - Gulati R
AD  - Genetic Services Unit, Department of Pediatrics, Jawaharlal Institute of 
      Postgraduate Medical Education & Research, Puducherry, India.
FAU - Negi, Vir Singh
AU  - Negi VS
AUID- ORCID: 0000-0003-1518-6031
AD  - Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical 
      Education & Research, Puducherry, India.
LA  - eng
GR  - JIP/Res/Intra-DM-M.Ch/01/2015-16/Intramural Grant, JIPMER, Puducherry/
PT  - Journal Article
DEP - 20190318
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Arthritis, Juvenile/diagnosis/epidemiology/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics/immunology
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Phenotype
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
OTO - NOTNLM
OT  - HLA
OT  - JIA
OT  - arthritis
OT  - enthesitis
OT  - pediatric
OT  - sacroiliitis
OT  - south Indian Tamils
EDAT- 2019/03/19 06:00
MHDA- 2020/01/30 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/05/31 00:00 [received]
PHST- 2019/02/02 00:00 [revised]
PHST- 2019/02/24 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - 10.1111/1756-185X.13551 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2019 Jul;22(7):1289-1296. doi: 10.1111/1756-185X.13551. Epub 
      2019 Mar 18.