PMID- 30884298
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 225
DP  - 2019 Jun
TI  - Evaluation of analytical performance of gas chromatography coupled with 
      atmospheric pressure chemical ionization Fourier transform ion cyclotron 
      resonance mass spectrometry (GC-APCI-FT-ICR-MS) in the target and non-targeted 
      analysis of brominated and chlorinated flame retardants in food.
PG  - 368-377
LID - S0045-6535(19)30483-7 [pii]
LID - 10.1016/j.chemosphere.2019.03.047 [doi]
AB  - A new analytical method was established and validated for the analysis of 
      eighteen halogenated flame retardants (HFRs)in food products. Gas chromatography 
      (GC) coupled to Fourier transform ion cyclotron resonance mass spectrometry 
      (FT-ICR-MS) employing atmospheric pressure chemical ionization (APCI) was used 
      for the identification and quantitation of contaminants. Intra-laboratory 
      validation of the method was performed with respect to recovery, repeatability, 
      linear calibration ranges, instrumental and method limits of quantitation (i-LOQ 
      and m-LOQ), and trueness was verified where possible by analysis of reference 
      materials (RMs). The validation results indicated recoveries of analytes between 
      59 and 115%, the repeatability in terms of relative standard deviations (RSDs) in 
      the range of 5-15% and linearity with correlation coefficients of >/=0.99 between 
      the i-LOQ and 250 pg injected on-column. The method i-LOQs ranged from  approximately 1 pg to 
       approximately 5 pg injected on-column, while m-LOQs were in the range of 0.002-0.04 ng g(-1) 
      sample. The measured values for RMs agreed with the provided values, giving the 
      accuracy of obtained concentrations in the range of 92-133% with RSD range of 
      2-15% and were in agreement with the results obtained with the reference method 
      based on magnetic sector GC-HRMS. For the majority of the compounds, the method 
      met a limit of quantification criterion stated in the Commission Recommendation, 
      2014/118/EU on monitoring BFRs in food. The developed method was demonstrated to 
      be suitable for qualitative screening of suspect target contaminants presented in 
      the samples by the post-run treatment of raw data and confirmation by isotope 
      cluster analysis.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Zacs, D
AU  - Zacs D
AD  - Institute of Food Safety, Animal Health and Environment "BIOR", Lejupes Iela 3, 
      Riga, LV, 1076, Latvia. Electronic address: dzintars.zachs@gmail.com.
FAU - Perkons, I
AU  - Perkons I
AD  - Institute of Food Safety, Animal Health and Environment "BIOR", Lejupes Iela 3, 
      Riga, LV, 1076, Latvia; University of Latvia, Jelgavas Iela 1, Riga, LV, 1004, 
      Latvia.
FAU - Bartkevics, V
AU  - Bartkevics V
AD  - Institute of Food Safety, Animal Health and Environment "BIOR", Lejupes Iela 3, 
      Riga, LV, 1076, Latvia; University of Latvia, Jelgavas Iela 1, Riga, LV, 1004, 
      Latvia.
LA  - eng
PT  - Journal Article
DEP - 20190312
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Cyclotrons
MH  - Flame Retardants/*analysis
MH  - Food
MH  - Food Analysis/*methods
MH  - Food Safety/*methods
MH  - *Fourier Analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Halogenated Diphenyl Ethers/*analysis
MH  - Halogenation
MH  - Humans
MH  - Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Commission recommendation 2014/118/EU
OT  - Food products
OT  - Fourier transform ion cyclotron resonance mass spectrometry
OT  - Halogenated flame retardants
OT  - Qualitative screening of suspect target contaminants
EDAT- 2019/03/19 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/12/14 00:00 [received]
PHST- 2019/02/27 00:00 [revised]
PHST- 2019/03/09 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - S0045-6535(19)30483-7 [pii]
AID - 10.1016/j.chemosphere.2019.03.047 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Jun;225:368-377. doi: 10.1016/j.chemosphere.2019.03.047. Epub 
      2019 Mar 12.