PMID- 30884420
OWN - NLM
STAT- MEDLINE
DCOM- 20191218
LR  - 20191218
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 172
DP  - 2019 May
TI  - Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 
      1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a 
      comparison of study designs.
PG  - 684-692
LID - S0013-9351(19)30124-0 [pii]
LID - 10.1016/j.envres.2019.02.047 [doi]
AB  - BACKGROUND: Human biomonitoring studies have demonstrated decreasing 
      concentrations of many persistent organic pollutants (POPs) in years after 
      emission peaks. OBJECTIVES: To describe time trends of POPs in blood using four 
      cross-sectional samples of 30 year olds from Tromso, Norway across 1986-2007, and 
      to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) 
      to model-estimated values. A second objective was to compare the repeated 
      cross-sectional time trends with those observed in our previous longitudinal 
      study using repeated individual measurements in older men from the same surveys. 
      METHODS: Serum from 45 persons aged 30 years in each of the following years: 
      1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted 
      concentrations of PCB-153 in each sampling year were derived using the 
      emission-based CoZMoMAN model. RESULTS: The median decreases in summed serum POP 
      concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were 
      - 71%, - 81%, and - 86% for women and - 65%, - 77%, and - 87% for men, 
      respectively. The overall time trend in predicted PCB-153 concentrations 
      demonstrated agreement with the observed trend although model predictions were 
      higher than the measured concentrations at all time points. Compared to our 
      previous longitudinal study of repeated individual measurements in older men, 
      similar although more prominent declines were observed in the younger 
      cross-sectional samples. DISCUSSION: Observed declines in serum concentrations 
      from 1986 to 2007 were substantial for legacy POPs in men and women at 
      reproductive ages in Northern Norway and are generally consistent with previous 
      longitudinal biomonitoring efforts in the study population. The measured 
      concentrations and observed declines likely reflect a combination of recent and 
      historic exposures. Small differences in time trends observed between the studies 
      could be attributed to different study designs (i.e. the chosen age group or sex 
      and cross-sectional versus repeated individual measurement sampling).
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Nost, Therese Haugdahl
AU  - Nost TH
AD  - Department of Community Medicine, UiT - The Arctic University of Norway, Tromso, 
      Norway; NILU-Norwegian Institute for Air Research, Fram Centre, Tromso, Norway. 
      Electronic address: therese.h.nost@uit.no.
FAU - Berg, Vivian
AU  - Berg V
AD  - Department of Medical Biology, UiT - The Arctic University of Norway, Tromso, 
      Norway.
FAU - Hanssen, Linda
AU  - Hanssen L
AD  - NILU-Norwegian Institute for Air Research, Fram Centre, Tromso, Norway.
FAU - Rylander, Charlotta
AU  - Rylander C
AD  - Department of Community Medicine, UiT - The Arctic University of Norway, Tromso, 
      Norway.
FAU - Gaudreau, Eric
AU  - Gaudreau E
AD  - Centre de toxicologie du Quebec, Institut national de sante publique du Quebec 
      (INSPQ), Quebec, Canada.
FAU - Dumas, Pierre
AU  - Dumas P
AD  - Centre de toxicologie du Quebec, Institut national de sante publique du Quebec 
      (INSPQ), Quebec, Canada.
FAU - Breivik, Knut
AU  - Breivik K
AD  - NILU-Norwegian Institute for Air Research, Kjeller, Norway; Department of 
      Chemistry, University of Oslo, Oslo, Norway.
FAU - Sandanger, Torkjel M
AU  - Sandanger TM
AD  - Department of Community Medicine, UiT - The Arctic University of Norway, Tromso, 
      Norway; NILU-Norwegian Institute for Air Research, Fram Centre, Tromso, Norway.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190301
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Environmental Monitoring
MH  - *Environmental Pollutants/blood
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Models, Theoretical
MH  - Norway
MH  - *Polychlorinated Biphenyls
OTO - NOTNLM
OT  - Cross-sectional time trends
OT  - Human biomonitoring
OT  - Modeling
OT  - POPs
OT  - Study design
EDAT- 2019/03/19 06:00
MHDA- 2019/12/19 06:00
CRDT- 2019/03/19 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2019/02/24 00:00 [revised]
PHST- 2019/02/28 00:00 [accepted]
PHST- 2019/03/19 06:00 [pubmed]
PHST- 2019/12/19 06:00 [medline]
PHST- 2019/03/19 06:00 [entrez]
AID - S0013-9351(19)30124-0 [pii]
AID - 10.1016/j.envres.2019.02.047 [doi]
PST - ppublish
SO  - Environ Res. 2019 May;172:684-692. doi: 10.1016/j.envres.2019.02.047. Epub 2019 
      Mar 1.