PMID- 30887274
OWN - NLM
STAT- MEDLINE
DCOM- 20190502
LR  - 20200225
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 109
IP  - 5
DP  - 2019 May
TI  - Light-chain plasma cell myeloma caused by 14q32/IGH translocation and loss of the 
      other allele.
PG  - 572-577
LID - 10.1007/s12185-019-02629-7 [doi]
AB  - Light-chain plasma cell myeloma (LC-PCM) is a PCM subtype in which only 
      immunoglobulin light-chain is secreted. However, the absence of immunoglobulin 
      heavy-chain (IGH) production in this condition has not been fully elucidated. To 
      address this issue, we retrospectively analyzed patients at our center with 
      LC-PCM and found a group who had only split signals of IGH gene derived from 
      14q32/IGH translocations by fluorescence in situ hybridization (FISH). Six 
      patients were identified with only split signals of the IGH gene derived from 
      14q32/IGH translocations. Five of these patients were newly diagnosed, while one 
      had IgG-lambda PCM at presentation, which transformed to lambda LC-PCM after treatment. The 
      translocation partners were identified in four patients: two cases of 
      (11;14)(q13;q32) and two cases of (4;14)(p16;q32). The development of LC-PCM 
      appears to be explained by the application of allelic exclusion in these 
      patients, such that 14q32/IGH translocation in one allele contributes to the 
      pathogenesis of PCM and the subsequent loss of the other allele is responsible 
      for the loss of IGH production. These findings suggest that a FISH pattern of IGH 
      with "split and loss" may constitute a unique subgroup of LC-PCM.
FAU - Nishio, Yuji
AU  - Nishio Y
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Sakai, Hirotaka
AU  - Sakai H
AUID- ORCID: 0000-0003-2677-7769
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan. hsakai@marianna-u.ac.jp.
FAU - Saiki, Yusuke
AU  - Saiki Y
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Uchida, Akiko
AU  - Uchida A
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Uemura, Yu
AU  - Uemura Y
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Matsunawa, Manabu
AU  - Matsunawa M
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Isobe, Yasushi
AU  - Isobe Y
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Kato, Masayuki
AU  - Kato M
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Tomita, Naoto
AU  - Tomita N
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
FAU - Miura, Ikuo
AU  - Miura I
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      216-8511, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190318
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin lambda-Chains)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Aged
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - *Immunoglobulin lambda-Chains
MH  - Leukemia, Plasma Cell/*genetics
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics
MH  - *Translocation, Genetic
OTO - NOTNLM
OT  - Allelic exclusion
OT  - Bence Jones protein
OT  - Chromosomal translocation
OT  - Class switch recombination
OT  - Immunoglobulin heavy-chain
EDAT- 2019/03/20 06:00
MHDA- 2019/05/03 06:00
CRDT- 2019/03/20 06:00
PHST- 2019/01/14 00:00 [received]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/03/09 00:00 [revised]
PHST- 2019/03/20 06:00 [pubmed]
PHST- 2019/05/03 06:00 [medline]
PHST- 2019/03/20 06:00 [entrez]
AID - 10.1007/s12185-019-02629-7 [pii]
AID - 10.1007/s12185-019-02629-7 [doi]
PST - ppublish
SO  - Int J Hematol. 2019 May;109(5):572-577. doi: 10.1007/s12185-019-02629-7. Epub 
      2019 Mar 18.