PMID- 30888496
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20221207
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 276
IP  - 6
DP  - 2019 Jun
TI  - Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in 
      chronic rhinosinusitis with nasal polyp.
PG  - 1685-1691
LID - 10.1007/s00405-019-05379-8 [doi]
AB  - OBJECTIVE: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic 
      inflammatory disease. The surrogate indicating biomarkers in patients with CRSwNP 
      need further evaluation. The aim of this study was to investigate the association 
      of thymic stromal lymphopoietin (TSLP) and amphiregulin (AREG) cytokines in 
      patients with CRSwNP. METHODS: Sinonasal tissue samples were collected from 33 
      patients with CRSwNP and 29 controls. Levels of AREG, IL-19, IL-21, IL-25, IL-33 
      and TSLP in nasal polyp and control sinonasal tissues were determined following 
      the enzyme-linked immunosorbent assay method. RESULTS: We found that AREG, IL-19, 
      IL-21, IL-25, IL-33 and TSLP levels were significantly higher in the CRSwNP group 
      compared to the control group (p < 0.000; p < 0.000; p < 0.000; p < 0.000; 
      p < 0.003; p < 0.021, respectively). CONCLUSIONS: Our findings indicated that 
      AREG, IL-19, IL-21, IL-25, IL-33 and TSLP were significantly increased in tissue 
      samples of CRSwNP patients and may be considered as molecular indicators and 
      targets for therapeutic developments for patients with CRSwNP.
FAU - Dogan, Murat
AU  - Dogan M
AD  - Department of Otolaryngology, Faculty of Medicine, Adnan Menderes University 
      Medical School, 09100, Aydin, Turkey.
FAU - Sahin, Mustafa
AU  - Sahin M
AUID- ORCID: 0000-0002-9009-6389
AD  - Department of Otolaryngology, Faculty of Medicine, Adnan Menderes University 
      Medical School, 09100, Aydin, Turkey. iskebaha@gmail.com.
FAU - Yenisey, Cigdem
AU  - Yenisey C
AD  - Department of Biochemistry, Adnan Menderes University Medical School, Aydin, 
      Turkey.
LA  - eng
GR  - TPF-16015./Adnan Menderes Universitesi/
PT  - Journal Article
DEP - 20190319
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Amphiregulin)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
MH  - Adult
MH  - Aged
MH  - Amphiregulin/*immunology
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Correlation of Data
MH  - Cytokines/*immunology
MH  - Female
MH  - Humans
MH  - Interleukins/classification/*immunology
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/diagnosis/immunology
MH  - Rhinitis/diagnosis/*immunology
MH  - Sinusitis/diagnosis/*immunology
MH  - Thymic Stromal Lymphopoietin
OTO - NOTNLM
OT  - Amphiregulin
OT  - Chronic rhinosinusitis
OT  - Cytokine
OT  - Nasal polyp
EDAT- 2019/03/20 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/03/20 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/03/20 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/03/20 06:00 [entrez]
AID - 10.1007/s00405-019-05379-8 [pii]
AID - 10.1007/s00405-019-05379-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1685-1691. doi: 
      10.1007/s00405-019-05379-8. Epub 2019 Mar 19.