PMID- 30888523
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2191-0855 (Print)
IS  - 2191-0855 (Electronic)
IS  - 2191-0855 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Mar 19
TI  - Synergistic and protective effect of atorvastatin and amygdalin against 
      histopathological and biochemical alterations in Sprague-Dawley rats with 
      experimental endometriosis.
PG  - 37
LID - 10.1186/s13568-019-0760-2 [doi]
LID - 37
AB  - The aim of the present study was to evaluate the protective effects of combined 
      atorvastatin and amygdalin in a rat model of endometriosis. Tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2) and 
      MMP-9 levels in the peritoneal fluid were determined. The expression of TNF-alpha, 
      IL-6, MMP-2, and MMP-9 mRNA, and the levels of lipid peroxidation, reduced 
      glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione 
      peroxidase (Gpx) were measured. Histopathological analysis was also conducted. 
      The results showed that peritoneal TNF-alpha, IL-6, MMP-2, and MMP-9 levels were 
      reduced by > 50%, and mRNA expression was decreased. Lipid peroxidation was 
      considerably reduced, while GSH, SOD, Gpx, and catalase levels increased 
      by > 40%. Reductions in leukocyte infiltration and fibrosis following treatment 
      were also observed. Thus, our study suggested that combined treatment consisting 
      of atorvastatin and amygdalin attenuates endometriosis. A detailed investigation 
      of molecular mechanism of atorvastatin and amygdalin in endometriosis is needed.
FAU - Hu, Fang
AU  - Hu F
AD  - Department of Reproductive Medicine, Maternal and Child Health Hospital of HuBei 
      Province, Wuhan, 430072, Hubei, China.
FAU - Hu, Yichuan
AU  - Hu Y
AD  - Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430072, Hubei, China.
FAU - Peng, Fangxin
AU  - Peng F
AD  - Department of Reproductive Medicine, Maternal and Child Health Hospital of HuBei 
      Province, Wuhan, 430072, Hubei, China. CreedBobetren@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20190319
PL  - Germany
TA  - AMB Express
JT  - AMB Express
JID - 101561785
PMC - PMC6424985
OTO - NOTNLM
OT  - Amygdalin
OT  - Atorvastatin
OT  - Cytokines
OT  - Endometriosis
OT  - Rats
COIS- The authors declare that they have no competing interests.
EDAT- 2019/03/20 06:00
MHDA- 2019/03/20 06:01
PMCR- 2019/03/19
CRDT- 2019/03/20 06:00
PHST- 2019/01/28 00:00 [received]
PHST- 2019/02/27 00:00 [accepted]
PHST- 2019/03/20 06:00 [entrez]
PHST- 2019/03/20 06:00 [pubmed]
PHST- 2019/03/20 06:01 [medline]
PHST- 2019/03/19 00:00 [pmc-release]
AID - 10.1186/s13568-019-0760-2 [pii]
AID - 760 [pii]
AID - 10.1186/s13568-019-0760-2 [doi]
PST - epublish
SO  - AMB Express. 2019 Mar 19;9(1):37. doi: 10.1186/s13568-019-0760-2.