PMID- 30890035 OWN - NLM STAT- MEDLINE DCOM- 20200522 LR - 20200522 IS - 2159-9777 (Electronic) IS - 0279-1072 (Linking) VI - 51 IP - 2 DP - 2019 Apr-Jun TI - Combining Cognitive-Behavioral Conjoint Therapy for PTSD with 3,4-Methylenedioxymethamphetamine (MDMA): A Case Example. PG - 166-173 LID - 10.1080/02791072.2019.1589028 [doi] AB - Treatments for posttraumatic stress disorder (PTSD) have evolved significantly in the past 35 years. From what was historically viewed as a pervasive, intractable condition have emerged multiple evidence-based intervention options. These treatments, predominantly cognitive behavioral in orientation, provide significant symptom improvement in 50-60% of recipients. The treatment of PTSD with MDMA-assisted psychotherapy using a supportive, non-directive approach has yielded promising results. It is unknown, however, how different therapeutic modalities could impact or improve outcomes. Therefore, to capitalize on the strengths of both approaches, Cognitive Behavioral Conjoint Therapy for PTSD (CBCT) was combined with MDMA in a small pilot trial. The current article provides a case study of one couple involved in the trial, chosen to provide a demographically representative example of the study participants and a case with a severe trauma history, to offer a detailed account of the methodology and choices made to integrate CBCT and MDMA, as well as an account of their experience through the treatment and their treatment gains. This article offers a description of the combination of CBCT for PTSD and MDMA, and demonstrates that it can produce reductions in PTSD symptoms and improvements in relationship satisfaction. FAU - Wagner, Anne C AU - Wagner AC AD - a Department of Psychology , Ryerson University , Toronto , Canada. AD - b Remedy , Toronto , Canada. FAU - Mithoefer, Michael C AU - Mithoefer MC AD - c Private Practice , Charleston , SC , USA. FAU - Mithoefer, Ann T AU - Mithoefer AT AD - c Private Practice , Charleston , SC , USA. FAU - Monson, Candice M AU - Monson CM AD - a Department of Psychology , Ryerson University , Toronto , Canada. LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190319 PL - United States TA - J Psychoactive Drugs JT - Journal of psychoactive drugs JID - 8113536 RN - 0 (Hallucinogens) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - Cognitive Behavioral Therapy/*methods MH - Combined Modality Therapy MH - Couples Therapy MH - Female MH - Hallucinogens/*administration & dosage MH - Humans MH - Male MH - Middle Aged MH - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage MH - Pilot Projects MH - Stress Disorders, Post-Traumatic/*therapy OTO - NOTNLM OT - CBT OT - MDMA OT - PTSD OT - couples EDAT- 2019/03/21 06:00 MHDA- 2020/05/23 06:00 CRDT- 2019/03/21 06:00 PHST- 2019/03/21 06:00 [pubmed] PHST- 2020/05/23 06:00 [medline] PHST- 2019/03/21 06:00 [entrez] AID - 10.1080/02791072.2019.1589028 [doi] PST - ppublish SO - J Psychoactive Drugs. 2019 Apr-Jun;51(2):166-173. doi: 10.1080/02791072.2019.1589028. Epub 2019 Mar 19.