PMID- 30890409
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20191217
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 126
DP  - 2019 Jun
TI  - Cerebrovascular inflammation: A critical trigger for neurovascular injury?
PG  - 165-177
LID - S0197-0186(19)30002-6 [pii]
LID - 10.1016/j.neuint.2019.03.011 [doi]
AB  - The cerebrovascular system is not only inert bystandard that support the 
      metabolic demands of the brain but also elicit the barrier functions against risk 
      factors mediated neurovascular injury. The onsets of cerebrovascular inflammation 
      are considered as stimuli that can provoke the host defense system and trigger 
      the development of neurological disorders. Homeostasis of the brain function is 
      regulated by the movement of endothelial, glial, and neuronal cells within the 
      neurovascular unit (NVU), which acts as a "platform" for the coordinated action 
      of anti- and pro-inflammatory mechanisms. The cerebrovascular system plays an 
      integral role in the inflammatory response by either producing or expressing a 
      variety of cytokines, adhesion molecules, metalloproteinases, and serine 
      proteases. Excessive inflammatory cytokine production can further be affecting 
      the blood-brain barrier (BBB) integrity and lead to brain tissue damage. In this 
      review, we summarize the more recent evidence highlighting the importance of 
      cerebrovascular injury in terms of risk prediction, and the mechanisms mediating 
      the upregulation of inflammatory mediators in cerebrovascular dysfunction and 
      neurodegeneration.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Naveed, Muhammad
AU  - Naveed M
AD  - Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of 
      Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, PR 
      China.
FAU - Zhou, Qi-Gang
AU  - Zhou QG
AD  - Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical 
      University, Nanjing, 211166, Jiangsu Province, PR China; Sir Run Run Hospital, 
      Nanjing Medical University, Nanjing, 211166, Jiangsu Province, PR China.
FAU - Han, Feng
AU  - Han F
AD  - Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of 
      Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, PR 
      China. Electronic address: fenghan169@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190316
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*immunology/metabolism
MH  - Brain/*immunology/metabolism
MH  - Brain Injuries/immunology/metabolism
MH  - Cerebrovascular Disorders/*immunology/metabolism
MH  - Humans
MH  - Inflammation/immunology/metabolism
MH  - Inflammation Mediators/*immunology/metabolism
MH  - Leukocytes/immunology/metabolism
MH  - Nervous System Diseases/immunology/metabolism
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Brain
OT  - Cerebrovascular inflammation
OT  - Cerebrovascular injury
OT  - Neurological disorder
EDAT- 2019/03/21 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/03/21 06:00
PHST- 2019/01/14 00:00 [received]
PHST- 2019/03/05 00:00 [revised]
PHST- 2019/03/12 00:00 [accepted]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/03/21 06:00 [entrez]
AID - S0197-0186(19)30002-6 [pii]
AID - 10.1016/j.neuint.2019.03.011 [doi]
PST - ppublish
SO  - Neurochem Int. 2019 Jun;126:165-177. doi: 10.1016/j.neuint.2019.03.011. Epub 2019 
      Mar 16.