PMID- 30890460
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 93
DP  - 2019 Jul 13
TI  - Structure/function interrelationships in patients with schizophrenia who have 
      persistent auditory verbal hallucinations: A multimodal MRI study using parallel 
      ICA.
PG  - 114-121
LID - S0278-5846(19)30001-6 [pii]
LID - 10.1016/j.pnpbp.2019.03.007 [doi]
AB  - There is accumulating neuroimaging evidence for both structural and functional 
      abnormalities in schizophrenia patients with persistent auditory verbal 
      hallucinations (AVH). So far, the direct interrelationships between altered 
      structural and functional changes underlying AVH are unknown. Recently, it has 
      become possible to reveal hidden patterns of neural dysfunction not sufficiently 
      captured by separate analysis of these two modalities. A data-driven fusion 
      method called parallel independent component analysis (p-ICA) is able to identify 
      maximally independent components of each imaging modality as well as the link 
      between them. In the present study, we utilized p-ICA to study covarying 
      components among gray matter volume maps computed from structural MRI (sMRI) and 
      fractional amplitude of low-frequency fluctuations (fALFF) maps computed from 
      resting-state functional MRI (rs-fMRI) data of 15 schizophrenia patients with 
      AVH, 16 non-hallucinating schizophrenia patients (nAVH), and 19 healthy controls 
      (HC). We found a significant correlation (r = 0.548, n = 50, p < .001) between a 
      sMRI component and a rs-fMRI component, which was significantly different between 
      the AVH and non AVH group (nAVH). The rs-fMRI component comprised temporal cortex 
      and cortical midline regions, the sMRI component included predominantly 
      fronto-temporo-parietal regions. Distinct clinical features, as measured by the 
      Psychotic Symptoms Rating Scale (PSYRATS), were associated with two different 
      modality specific rs-fMRI components. There was a significant correlation between 
      a predominantly parietal resting-state network and the physical dimension of 
      PSYRATS and the posterior cingulate/temporal cortex network and the emotional 
      dimension of PSYRATS. These data suggest AVH-specific interrelationships between 
      intrinsic network activity and GMV, together with modality-specific associations 
      with distinct symptom dimensions of AVH.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Kubera, Katharina M
AU  - Kubera KM
AD  - Center for Psychosocial Medicine, Department of General Psychiatry, University of 
      Heidelberg, Germany.
FAU - Rashidi, Mahmoud
AU  - Rashidi M
AD  - Center for Psychosocial Medicine, Department of General Psychiatry, University of 
      Heidelberg, Germany.
FAU - Schmitgen, Mike M
AU  - Schmitgen MM
AD  - Center for Psychosocial Medicine, Department of General Psychiatry, University of 
      Heidelberg, Germany.
FAU - Barth, Anja
AU  - Barth A
AD  - Center for Psychosocial Medicine, Department of General Psychiatry, University of 
      Heidelberg, Germany.
FAU - Hirjak, Dusan
AU  - Hirjak D
AD  - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Sambataro, Fabio
AU  - Sambataro F
AD  - Department of Medicine (DAME), Udine University, Italy.
FAU - Calhoun, Vince D
AU  - Calhoun VD
AD  - Department of Electrical and Computer Engineering, The University of New Mexico 
      and the Mind Research Network, Albuquerque, NM, USA.
FAU - Wolf, Robert C
AU  - Wolf RC
AD  - Center for Psychosocial Medicine, Department of General Psychiatry, University of 
      Heidelberg, Germany. Electronic address: christian.wolf@med.uni-heidelberg.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190316
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/pathology/*physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Functional Neuroimaging
MH  - Hallucinations/diagnostic imaging/pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnostic imaging/pathology/*physiopathology
OTO - NOTNLM
OT  - Auditory verbal hallucinations
OT  - Magnetic resonance imaging
OT  - Parallel independent component analysis
OT  - Schizophrenia
EDAT- 2019/03/21 06:00
MHDA- 2020/02/15 06:00
CRDT- 2019/03/21 06:00
PHST- 2019/01/01 00:00 [received]
PHST- 2019/02/28 00:00 [revised]
PHST- 2019/03/13 00:00 [accepted]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/03/21 06:00 [entrez]
AID - S0278-5846(19)30001-6 [pii]
AID - 10.1016/j.pnpbp.2019.03.007 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:114-121. doi: 
      10.1016/j.pnpbp.2019.03.007. Epub 2019 Mar 16.