PMID- 30890774
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20221207
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 120
IP  - 8
DP  - 2019 Apr
TI  - Serious adverse events in African-American cancer patients with sickle cell trait 
      and inherited haemoglobinopathies in a SEER-Medicare claims cohort.
PG  - 861-863
LID - 10.1038/s41416-019-0416-7 [doi]
AB  - African-American (AA) cancer patients have long-experienced worse outcomes 
      compared to non-Hispanic whites (NHW). No studies to date have evaluated the 
      prognostic impact of sickle cell trait (SCT) and other inherited 
      haemoglobinopathies, of which several are disproportionately high in the AA 
      population. In a cohort analysis of treated patients diagnosed with breast or 
      prostate cancer in the linked SEER-Medicare database, the relative risk (RR) for 
      >/=1 serious adverse events (AEs), defined as hospitalisations or emergency 
      department visits, was estimated for 371 AA patients with a haemoglobinopathy 
      (AA+) compared to patients without haemoglobinopathies (17,303 AA-; 144,863 
      NHW-). AA+ patients had significantly increased risk for >/=1 AEs compared to AA- 
      (RR = 1.19; 95% CI 1.11-1.27) and NHW- (RR = 1.23; 95% CI 1.15-1.31) patients. 
      The magnitude of effect was similar by cancer type, and in analyses of AA+ with 
      SCT only. Our findings suggest a novel hypothesis for disparities in cancer 
      outcomes.
FAU - Hoag, Jessica R
AU  - Hoag JR
AD  - Department of Internal Medicine, Cancer Outcomes, Public Policy, and 
      Effectiveness Research Center, Yale University School of Medicine, New Haven, CT, 
      USA.
FAU - Andemariam, Biree
AU  - Andemariam B
AD  - New England Sickle Cell Institute, Division of Hematology/Oncology, Neag 
      Comprehensive Cancer Center, UConn Health, Farmington, CT, USA.
FAU - Wang, Xiaoyan
AU  - Wang X
AD  - Center for Quantitative Medicine, UConn School of Medicine, Farmington, CT, USA.
FAU - Gregorio, David I
AU  - Gregorio DI
AD  - Department of Community Medicine and Health Care, UConn School of Medicine, 
      Farmington, CT, USA.
FAU - Jones, Beth A
AU  - Jones BA
AD  - Department of Chronic Disease Epidemiology, Yale School of Public Health, New 
      Haven, CT, USA.
FAU - Sporn, Jonathan
AU  - Sporn J
AD  - Department of Hematology-Oncology, St. Francis Hospital and Medical Center, 
      Hartford, CT, USA.
FAU - Salner, Andrew L
AU  - Salner AL
AD  - Hartford Health Care Cancer Institute, Hartford Hospital, Hartford, CT, USA.
FAU - Swede, Helen
AU  - Swede H
AUID- ORCID: 0000-0002-6707-7964
AD  - Department of Community Medicine and Health Care, UConn School of Medicine, 
      Farmington, CT, USA. swede@uchc.edu.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190320
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
SB  - IM
MH  - *Black or African American
MH  - Drug-Related Side Effects and Adverse Reactions/pathology
MH  - Female
MH  - Hemoglobinopathies/blood/complications/*epidemiology/pathology
MH  - Humans
MH  - Male
MH  - Medicare
MH  - Neoplasms/blood/complications/*epidemiology/pathology
MH  - Patients
MH  - Risk Factors
MH  - SEER Program
MH  - Sickle Cell Trait/blood/complications/*epidemiology/pathology
MH  - United States/epidemiology
MH  - White People
PMC - PMC6474269
COIS- The authors declare no competing interests.
EDAT- 2019/03/21 06:00
MHDA- 2020/02/28 06:00
PMCR- 2020/03/20
CRDT- 2019/03/21 06:00
PHST- 2018/07/20 00:00 [received]
PHST- 2019/02/12 00:00 [accepted]
PHST- 2019/02/04 00:00 [revised]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2019/03/21 06:00 [entrez]
PHST- 2020/03/20 00:00 [pmc-release]
AID - 10.1038/s41416-019-0416-7 [pii]
AID - 416 [pii]
AID - 10.1038/s41416-019-0416-7 [doi]
PST - ppublish
SO  - Br J Cancer. 2019 Apr;120(8):861-863. doi: 10.1038/s41416-019-0416-7. Epub 2019 
      Mar 20.