PMID- 30891154
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 10
IP  - 3
DP  - 2019 Mar 15
TI  - Targeted genotyping for the prediction of celiac disease autoimmunity development 
      in patients with type 1 diabetes and their family members.
PG  - 189-199
LID - 10.4239/wjd.v10.i3.189 [doi]
AB  - BACKGROUND: Patients with type 1 diabetes (T1D) and their first-degree relatives 
      (FDRs) have an increased risk of developing celiac disease (CD) compared to the 
      general population. This is largely explained by the shared association with 
      major histocompatibility class II human leukocyte antigen (HLA) DQ2 and/or DQ8 
      between the two disease states. AIM: To describe the frequency of CD autoimmunity 
      (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D 
      and their FDRs. Additionally, we aimed at identifying predictors associated with 
      an increased risk of developing CDA in patients with T1D and their family 
      members. METHODS: We obtained clinical information and blood samples from 1027 
      participants (302 with T1D and 725 FDRs) over a five-year period. Samples were 
      tested for autoantibodies associated with CD, HLA-DQ alleles, and haptoglobin 
      genotype. We fit univariate and multiple logistic regression models for CDA 
      separately for subjects with T1D and for FDRs of subjects with T1D. RESULTS: 
      Implementation of a screening program increased the frequency of CDA by 2-fold in 
      participants with T1D and 2.8-fold in their FDRs. Multivariate analysis found 
      that, in participants with T1D, having both DR7-DQ2 and DR4-DQ8 was associated 
      with an increased frequency of CDA. In FDRs of T1D patients, reported CD in the 
      family was associated with an increased frequency of CDA during screening. 
      Haptoglobin 2 genotype was not associated with developing CDA in the multivariate 
      analysis. CONCLUSION: Patients with T1D and their FDRs have a high frequency of 
      CDA. Carrying both DR7-DQ2 and DR4-DQ8 was associated with development of CDA in 
      patients with T1D.
FAU - Leonard, Maureen M
AU  - Leonard MM
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
FAU - Camhi, Stephanie
AU  - Camhi S
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
FAU - Kenyon, Victoria
AU  - Kenyon V
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
FAU - Betensky, Rebecca A
AU  - Betensky RA
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA 02115, United States.
FAU - Sturgeon, Craig
AU  - Sturgeon C
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
FAU - Yan, Shu
AU  - Yan S
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
FAU - Fasano, Alessio
AU  - Fasano A
AD  - Mucosal Immunology and Biology Research Center, Mass General Hospital for 
      Children, Boston, MA 02115, United States.
LA  - eng
GR  - F32 DK109620/DK/NIDDK NIH HHS/United States
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC6422857
OTO - NOTNLM
OT  - Coeliac
OT  - Diabetic
OT  - Gluten
OT  - Haptoglobin
OT  - Human leukocyte antigen
OT  - Screening
COIS- Conflict-of-interest statement: The authors declare no conflict of interest.
EDAT- 2019/03/21 06:00
MHDA- 2019/03/21 06:01
PMCR- 2019/03/15
CRDT- 2019/03/21 06:00
PHST- 2019/02/06 00:00 [received]
PHST- 2019/03/04 00:00 [revised]
PHST- 2019/03/08 00:00 [accepted]
PHST- 2019/03/21 06:00 [entrez]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2019/03/21 06:01 [medline]
PHST- 2019/03/15 00:00 [pmc-release]
AID - 10.4239/wjd.v10.i3.189 [doi]
PST - ppublish
SO  - World J Diabetes. 2019 Mar 15;10(3):189-199. doi: 10.4239/wjd.v10.i3.189.