PMID- 30891260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2054-5703 (Print)
IS  - 2054-5703 (Electronic)
IS  - 2054-5703 (Linking)
VI  - 6
IP  - 2
DP  - 2019 Feb
TI  - Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats.
PG  - 181081
LID - 10.1098/rsos.181081 [doi]
LID - 181081
AB  - Allergic rhinitis (AR) is a global health problem that appears in all age groups 
      and affects approximately 15-30% of people. Baicalin has been used for the 
      treatment of various allergic diseases, including AR. However, the metabolic 
      mechanisms of AR and baicalin against AR have not been systematically studied. 
      Here, ovalbumin-sensitized AR rats were used as a model, and animal behaviour, 
      histological analysis, enzyme-linked immunosorbent assay (ELISA) and metabolomics 
      were used to elucidate the mechanism of baicalin for AR. The results indicated 
      that baicalin has a protective effect on AR rats by inhibiting the release of 
      immunoglobulin E (IgE), histamine, interleukin-1 beta (IL-1beta), interleukin-4 
      (IL-4), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). In 
      addition, ovalbumin-induced AR included modulation of arachidonic acid, 
      leukotriene A4 (LTA4), leukotriene B4 (LTB4), alpha-ketoglutaric acid, 
      phosphatidylcholine PC (20 : 4/0 : 0), PC (16 : 0/0 : 0), citric acid, fumarate, 
      malate, 3-methylhistidine, histamine and other amino acids that are involved in 
      arachidonic acid, histidine metabolism, the TCA cycle and amino acid metabolism. 
      Thus, AR could be alleviated or reversed by baicalin.
FAU - Chen, Saizhen
AU  - Chen S
AUID- ORCID: 0000-0001-5830-4005
AD  - Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, People's 
      Republic of China.
FAU - Chen, Guirong
AU  - Chen G
AD  - Liaoning University of Traditional Chinese Medicine, Shenyang 110847, People's 
      Republic of China.
FAU - Shu, Sheng
AU  - Shu S
AD  - Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, People's 
      Republic of China.
FAU - Xu, Yubin
AU  - Xu Y
AD  - Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, People's 
      Republic of China.
FAU - Ma, Xiande
AU  - Ma X
AD  - Liaoning University of Traditional Chinese Medicine, Shenyang 110847, People's 
      Republic of China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.c.4391372
PT  - Journal Article
DEP - 20190220
PL  - England
TA  - R Soc Open Sci
JT  - Royal Society open science
JID - 101647528
PMC - PMC6408364
OTO - NOTNLM
OT  - allergic rhinitis
OT  - baicalin
OT  - metabolomics
COIS- We have no competing interests.
EDAT- 2019/03/21 06:00
MHDA- 2019/03/21 06:01
PMCR- 2019/02/20
CRDT- 2019/03/21 06:00
PHST- 2018/07/03 00:00 [received]
PHST- 2019/01/25 00:00 [accepted]
PHST- 2019/03/21 06:00 [entrez]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2019/03/21 06:01 [medline]
PHST- 2019/02/20 00:00 [pmc-release]
AID - rsos181081 [pii]
AID - 10.1098/rsos.181081 [doi]
PST - epublish
SO  - R Soc Open Sci. 2019 Feb 20;6(2):181081. doi: 10.1098/rsos.181081. eCollection 
      2019 Feb.