PMID- 30891338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 10
IP  - 3
DP  - 2019 Mar 1
TI  - In vivo monitoring and high-resolution characterizing of the prednisolone-induced 
      osteoporotic process on adult zebrafish by optical coherence tomography.
PG  - 1184-1195
LID - 10.1364/BOE.10.001184 [doi]
AB  - Because of its similar genetic makeup with humans, zebrafish are an available and 
      well-established osteoporosis model in vivo for anti-osteoporosis drug 
      development as well as the drug safety-evaluation process. However, few optical 
      imaging methods could effectively visualize the bone of adult zebrafish due to 
      their limited penetration depth. In this paper, in vivo high-resolution and 
      long-term characterization of a prednisolone-induced osteoporotic zebrafish model 
      was achieved with spectral-domain optical coherence tomography (SD-OCT). The 
      capability of three-dimensional SD-OCT imaging was also demonstrated in this 
      study. With SD-OCT images, we could non-destructively monitor the deforming 
      process of adult zebrafish skull from several directions at any time. There is 
      good correlation and agreement between SD-OCT and histology. Valuable phenomenon 
      such as bone defects could be quantitatively evaluated using the SD-OCT images at 
      different time points during a period of 21 days.
FAU - Lin, Yanping
AU  - Lin Y
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
FAU - Xiang, Xiang
AU  - Xiang X
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
FAU - Chen, Tingru
AU  - Chen T
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
FAU - Gao, Chudan
AU  - Gao C
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
FAU - Fu, Hongbo
AU  - Fu H
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
FAU - Wang, Limei
AU  - Wang L
AD  - Center for Drug Non-clinical Evaluation and Research, Guangdong Biological 
      Resources Institute, Guangdong Academy of Sciences, Guangzhou 510900, China.
FAU - Deng, Lijun
AU  - Deng L
AD  - Key Lab of Optic-Electronic and Communication, Jiangxi Sciences and Technology 
      Normal University, Nanchang 330038, China.
FAU - Zeng, Lvming
AU  - Zeng L
AD  - Key Lab of Optic-Electronic and Communication, Jiangxi Sciences and Technology 
      Normal University, Nanchang 330038, China.
AD  - School of Electromechanical Engineering, Guangdong University of Technology, 
      Guangzhou 510006, Guangdong, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - School of Basic Medical Science, Affiliated Stomatology Hospital of Guangzhou 
      Medical University, Guangzhou Medical University, Guangzhou 511436, China.
LA  - eng
PT  - Journal Article
DEP - 20190211
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC6420289
COIS- The authors declare that there are no conflicts of interest related to this 
      article.
EDAT- 2019/03/21 06:00
MHDA- 2019/03/21 06:01
PMCR- 2019/02/11
CRDT- 2019/03/21 06:00
PHST- 2018/11/28 00:00 [received]
PHST- 2019/01/16 00:00 [revised]
PHST- 2019/01/27 00:00 [accepted]
PHST- 2019/03/21 06:00 [entrez]
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2019/03/21 06:01 [medline]
PHST- 2019/02/11 00:00 [pmc-release]
AID - 353075 [pii]
AID - 10.1364/BOE.10.001184 [doi]
PST - epublish
SO  - Biomed Opt Express. 2019 Feb 11;10(3):1184-1195. doi: 10.1364/BOE.10.001184. 
      eCollection 2019 Mar 1.