PMID- 30893257
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 82
IP  - 4
DP  - 2019 Apr
TI  - Elevated matrix metalloproteinase-3 level may affect hearing function in patients 
      with rheumatoid arthritis.
PG  - 272-276
LID - 10.1097/JCMA.0000000000000036 [doi]
AB  - BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease. Sensorineural and 
      conductive hearing loss have been reported in RA, but the results of most studies 
      are not in agreement. The pathogenesis of the hearing loss is not clearly 
      understood. The presence of sensorineural hearing loss was related to matrix 
      metalloproteinase-3 (MMP-3). The aim of this study was to assess hearing loss in 
      RA patients and to examine the correlation between plasma MMP-3 levels and 
      hearing loss in such patients. METHODS: This is a cross-sectional and analytic 
      research. Subjects consisted of 21 RA patients with hearing loss as a study group 
      and 21 RA patients without hearing loss as controls. All patients were evaluated 
      by pure tone audiometry and tympanometry. The amounts of plasma MMP-3 were 
      determined using enzyme-linked immunosorbent assay. Pearson Chi-square test was 
      used to determine the correlation of gender, age, disease duration, erythrocyte 
      sedimentation rate, and platelet count of both groups. Independent t-test was 
      used to assess equality of mean values at 250 to 8000 Hz hearing thresholds, pure 
      tone mean values, air-bone gaps, and MMP-3 plasma levels of both groups. RESULTS: 
      This study found sensorineural (76.2%), conductive (14.3%), and mixed (9.5%) 
      hearing loss. The most common degree of hearing loss was mild (66.7%). There was 
      an increased incidence of As-type tympanogram in the study group (28.6%) and 
      control group (47.6%). There were significant differences between both groups in 
      mean hearing thresholds (p < 0.001), mean of air conduction thresholds at 1000 to 
      8000 Hz (p < 0.05), and mean of bone conduction thresholds in all frequencies (p 
      < 0.05). The significant difference of mean MMP-3 levels was also found between 
      the groups (p < 0.001). CONCLUSION: Hearing loss is a common finding in RA. MMP-3 
      plasma contributed to degrade the incudomalleolar and incudostapedial joints and 
      could damage the inner ear hair cells due to oxidative process in RA.
FAU - Nasution, Muhammad Edy Syahputra
AU  - Nasution MES
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, 
      University of Muhammadiyah Sumatera Utara, Medan, Sumatera Utara, Indonesia.
FAU - Haryuna, Tengku Siti Hajar
AU  - Haryuna TSH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, 
      Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*complications/enzymology
MH  - Auditory Threshold
MH  - Autoimmunity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hearing Loss, Sensorineural/*etiology
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/blood/*physiology
MH  - Middle Aged
EDAT- 2019/03/21 06:00
MHDA- 2020/03/10 06:00
CRDT- 2019/03/21 06:00
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/03/21 06:00 [entrez]
AID - 10.1097/JCMA.0000000000000036 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2019 Apr;82(4):272-276. doi: 10.1097/JCMA.0000000000000036.