PMID- 30893262
OWN - NLM
STAT- MEDLINE
DCOM- 20200717
LR  - 20200717
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 82
IP  - 8
DP  - 2019 Aug
TI  - Evaluation of oxidative stress and antioxidant capacity in healthy children.
PG  - 651-654
LID - 10.1097/JCMA.0000000000000045 [doi]
AB  - BACKGROUND: Measurement of the levels of the derivatives of reactive oxygen 
      metabolites (d-ROMs) and of the biological antioxidant potential (BAP) enables 
      simultaneous assessment of oxidation degree and antioxidant capacity, using the 
      same sample and testing equipment. At present, reference values of healthy adults 
      are clarified, but the reference value of healthy children is unknown. This study 
      was undertaken to clarify the age-related changes and the reference values of 
      d-ROMs and BAP in healthy children. METHODS: The study population consisted of 77 
      children, ranging in age from 2 to 15 years, in normal mental and physical health 
      as examined by a pediatrician, and seven healthy adult volunteers. Serum samples 
      were obtained from the subjects for assay. Using these samples, d-ROMs and BAP 
      values were measured, and the relationship with age was analyzed. RESULTS: The 
      d-ROMs level decreased as the age increased, while the BAP showed no correlation 
      with the age. The d-ROMs level was significantly higher in 2-6 years group than 
      in 7-11 years group, 12-15 years group, or healthy adults group. The BAP/d-ROMs 
      ratio, an index of antioxidant capacity, increased significantly with higher age. 
      CONCLUSION: This study was carried out for the first time in healthy children in 
      oxidative stress assessment using d-ROMs and BAP. In the infancy 2-6 years, the 
      d-ROMs value was significantly higher and the BAP/d-ROMs ratio was significantly 
      lower. From this, it was suggested that age should be considered when performing 
      oxidative stress assessment using d-ROMs and BAP in children.
FAU - Morimoto, Masahito
AU  - Morimoto M
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Hashimoto, Toshiaki
AU  - Hashimoto T
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Tsuda, Yoshimi
AU  - Tsuda Y
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Kitaoka, Taisuke
AU  - Kitaoka T
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
FAU - Kyotani, Shojiro
AU  - Kyotani S
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine/urine
MH  - Adolescent
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Young Adult
EDAT- 2019/03/21 06:00
MHDA- 2020/07/18 06:00
CRDT- 2019/03/21 06:00
PHST- 2019/03/21 06:00 [pubmed]
PHST- 2020/07/18 06:00 [medline]
PHST- 2019/03/21 06:00 [entrez]
AID - 10.1097/JCMA.0000000000000045 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2019 Aug;82(8):651-654. doi: 10.1097/JCMA.0000000000000045.