PMID- 30895006
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2213-8862 (Electronic)
IS  - 1991-7902 (Print)
IS  - 1991-7902 (Linking)
VI  - 11
IP  - 4
DP  - 2016 Dec
TI  - Matrix metalloproteinase-2, -9, and tissue inhibitor of MMP-2 gene polymorphisms 
      in Taiwanese periodontitis patients.
PG  - 411-418
LID - 10.1016/j.jds.2016.07.001 [doi]
AB  - BACKGROUND/PURPOSE: Matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs 
      (TIMPs) have been shown to play an important role in the pathogenesis of tissue 
      destruction in periodontitis. The associations between single nucleotide 
      polymorphisms (SNPs) in the promoter regions of MMP-2, MMP-9, and TIMP-2 genes 
      and the risk of aggressive periodontitis (AgP) and chronic periodontitis (CP) 
      were investigated in a Taiwanese population. MATERIALS AND METHODS: 
      MMP-2 C-1306T, C-735T, T-790G, and MMP-9 C-1562T and TIMP-2 G-418C SNPs were 
      genotyped by polymerase chain reaction-restriction fragment length polymorphism 
      analysis in 69 patients and 129 patients with AgP and CP, respectively, and 117 
      periodontal healthy individuals who served as healthy controls (HC). Chi-square 
      test and logistic regression analysis were used to investigate the possible 
      association of genotypes with periodontitis. RESULTS: No significant differences 
      in the distributions of the C-1306T and C-735T variants between periodontitis and 
      HC were detected. Patients with genotype of MMP-2 -790 TT or T allele of 
      MMP-2-790T/G as compared to genotypes of GT + GG genotypes or G allele, were less 
      susceptible to CP [odds ratio (OR) = 0.50, 95% confidence interval 
      (CI) = 0.25-1.00 and OR = 0.52, 95% CI = 0.28-0.96, respectively]. The 
      frequencies of TIMP-2 G-418C gene polymorphisms in nonsmokers were statistically 
      significantly different among AgP, CP, and HC groups (P = 0.024). The nonalcohol 
      drinking participants with C allele of MMP-9 C-1562T as compared to T allele, 
      were less susceptible to AgP (adjusted OR = 0.4; 95% CI, 0.18-0.90). CONCLUSION: 
      It is suggested that MMP-2 T-790G, MMP-9 C-1562T, and TIMP-2 G-418C gene 
      polymorphisms might be associated with periodontitis in the Taiwanese Han 
      population.
FAU - Hsiao, Yu-Feng
AU  - Hsiao YF
AD  - Institute of Biomedical Nutrition, Hungkuang University, Taichung, Taiwan.
FAU - Yang, Li-Chiu
AU  - Yang LC
AD  - Periodontics, University Hospital and College of Oral Medicine, Chung Shan 
      Medical University, Taichung, Taiwan.
FAU - Chou, Yu-Shian
AU  - Chou YS
AD  - Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
FAU - Ho, Ya-Ping
AU  - Ho YP
AD  - Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
AD  - College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Lin, Ying-Chu
AU  - Lin YC
AD  - College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Ho, Kun-Yen
AU  - Ho KY
AD  - Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
AD  - College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Wu, Yi-Min
AU  - Wu YM
AD  - Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
AD  - College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Tsai, Chi-Cheng
AU  - Tsai CC
AD  - Periodontics, University Hospital and College of Oral Medicine, Chung Shan 
      Medical University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20160809
PL  - Netherlands
TA  - J Dent Sci
JT  - Journal of dental sciences
JID - 101293181
PMC - PMC6395246
OTO - NOTNLM
OT  - MMP-2
OT  - MMP-9
OT  - TIMP-2
OT  - Taiwanese
OT  - gene polymorphism
OT  - periodontitis
EDAT- 2016/12/01 00:00
MHDA- 2016/12/01 00:01
PMCR- 2016/08/09
CRDT- 2019/03/22 06:00
PHST- 2016/05/27 00:00 [received]
PHST- 2016/07/01 00:00 [revised]
PHST- 2019/03/22 06:00 [entrez]
PHST- 2016/12/01 00:00 [pubmed]
PHST- 2016/12/01 00:01 [medline]
PHST- 2016/08/09 00:00 [pmc-release]
AID - S1991-7902(16)30057-5 [pii]
AID - 10.1016/j.jds.2016.07.001 [doi]
PST - ppublish
SO  - J Dent Sci. 2016 Dec;11(4):411-418. doi: 10.1016/j.jds.2016.07.001. Epub 2016 Aug 
      9.