PMID- 30896336
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 30
IP  - 8
DP  - 2019 Jun
TI  - Sodium carboxymethyl cellulose hydrogels containing reduced graphene oxide (rGO) 
      as a functional antibiofilm wound dressing.
PG  - 629-645
LID - 10.1080/09205063.2019.1595892 [doi]
AB  - Biofilms comprise bacteria attached to wound surfaces and are major contributors 
      to non-healing wounds. It was found that the increased resistance of biofilms to 
      antibiotics allows wound infections to persist chronically in spite of antibiotic 
      therapy. In this study, the reduced form of graphene oxide (rGO) was explored as 
      plausible antibiofilm agents. The rGO was synthesized via reducing the functional 
      groups of GO. Then, rGO were characterized using zetasizer, X-ray photoelectron 
      spectroscopy, UV-Vis spectroscopy and FESEM. The rGO were then formulated into 
      sodium carboxymethyl cellulose (NaCMC) hydrogels to form rGO hydrogel and tested 
      for antibiofilm activities in vitro using XTT test, and in vivo biofilm formation 
      assay using nematodes C. elegans. Reduced GO hydrogel was successfully formed by 
      reducing the functional groups of GO, and a reduction of up to 95% of functional 
      groups was confirmed with X-ray photoelectron spectroscopy analysis. XTT tests 
      confirmed that rGO hydrogels reduced biofilm formation by S. aureus (81-84%) and 
      P. aeruginosa (50-62%). Fluorescence intensity also confirmed that rGO hydrogel 
      can inhibit biofilm bacteria in C. elegans experiments. This study implied that 
      rGO hydrogel is an effective antibiofilm agent for infected wounds.
FAU - Ali, Nor Hazwan
AU  - Ali NH
AD  - a Centre for Drug Delivery Research, Fakulti Farmasi , Universiti Kebangsaan 
      Malaysia , Kuala Lumpur , Malaysia.
FAU - Amin, Mohd Cairul Iqbal Mohd
AU  - Amin MCIM
AD  - a Centre for Drug Delivery Research, Fakulti Farmasi , Universiti Kebangsaan 
      Malaysia , Kuala Lumpur , Malaysia.
FAU - Ng, Shiow-Fern
AU  - Ng SF
AD  - a Centre for Drug Delivery Research, Fakulti Farmasi , Universiti Kebangsaan 
      Malaysia , Kuala Lumpur , Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190404
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydrogels)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - K679OBS311 (Carboxymethylcellulose Sodium)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Bandages
MH  - Biofilms
MH  - Caenorhabditis elegans/drug effects
MH  - Carboxymethylcellulose Sodium/*chemistry/pharmacology
MH  - Cell Line
MH  - Cell Survival
MH  - Drug Compounding/methods
MH  - Graphite/*chemistry
MH  - Humans
MH  - Hydrogels/*chemistry/pharmacology
MH  - Oxidation-Reduction
MH  - Pseudomonas aeruginosa/drug effects
MH  - Staphylococcus aureus/drug effects
MH  - Wound Healing/drug effects
OTO - NOTNLM
OT  - Reduced graphene oxide
OT  - antibiofilm
OT  - sodium carboxymethyl cellulose
OT  - wound dressing
EDAT- 2019/03/22 06:00
MHDA- 2020/03/24 06:00
CRDT- 2019/03/22 06:00
PHST- 2019/03/22 06:00 [pubmed]
PHST- 2020/03/24 06:00 [medline]
PHST- 2019/03/22 06:00 [entrez]
AID - 10.1080/09205063.2019.1595892 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2019 Jun;30(8):629-645. doi: 
      10.1080/09205063.2019.1595892. Epub 2019 Apr 4.