PMID- 3089792
OWN - NLM
STAT- MEDLINE
DCOM- 19860916
LR  - 20190813
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 145
IP  - 1-2
DP  - 1986 Apr
TI  - Fatty acid composition of plasma lipids in Nigerian children with protein-energy 
      malnutrition.
PG  - 109-15
AB  - The fatty acid (FA) composition of the main plasma lipids was analysed in eight 
      well-nourished, generally healthy Nigerian children aged 14.1 +/- 7.2 months and 
      in 17 malnourished children (8 marasmus, 9 kwashiorkor) aged 14.6 +/- 3.8 months 
      within the first 2 days of admission at the Dept. of Child Health, University of 
      Benin. In comparison to the control group, the malnourished children showed a 
      marked decrease of polyunsaturated FA with low linoleic acid, mainly in sterol 
      esters (STE), and severely reduced linoleic acid metabolites, including 
      arachidonic acid, in all lipid fractions. omega-3-FA were not altered except for 
      a reduction of docosapentaenoic and docosahexaenoic acids in phospholipids. 
      Clearly increased values were found for saturated FA in STE and for the 
      non-essential monoenoic FA in all lipid classes. This pattern indicates the 
      presence of essential fatty acid deficiency in the malnourished children. There 
      was no significant difference between marasmus and kwashiorkor. Eight 
      malnourished children were followed up in the early phase of recovery during 
      hospital treatment 14.0 +/- 3.1 days after obtaining the first sample. Linoleic 
      acid had increased again in STE, but its metabolites were as low or even lower 
      than before. An impaired activity of delta-6-desaturase, the rate limiting enzyme 
      of linoleic acid metabolism, in suggested by elevated substrate-product-ratios of 
      this enzyme in untreated children with protein energy malnutrition and in the 
      early phase of recovery, which may be due to low insulin levels, protein and zinc 
      deficiency. The trientetraen ratio (20:3 omega 9/20:4 omega 6) thus is not a 
      reliable indicator of essential FA status in protein-energy malnutrition.
FAU - Koletzko, B
AU  - Koletzko B
FAU - Abiodun, P O
AU  - Abiodun PO
FAU - Laryea, M D
AU  - Laryea MD
FAU - Bremer, H J
AU  - Bremer HJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (Arachidonic Acids)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Essential)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Linoleic Acids)
RN  - 0 (Oleic Acids)
RN  - 0 (Phospholipids)
RN  - 0 (Triglycerides)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - EC 1.14.19.- (Fatty Acid Desaturases)
RN  - EC 1.14.19.3 (Linoleoyl-CoA Desaturase)
SB  - IM
MH  - Arachidonic Acid
MH  - Arachidonic Acids/biosynthesis/blood
MH  - Fatty Acid Desaturases/metabolism
MH  - Fatty Acids/*blood
MH  - Fatty Acids, Essential/deficiency
MH  - Fatty Acids, Unsaturated/blood
MH  - Humans
MH  - Infant
MH  - Infant Nutrition Disorders/*blood/metabolism
MH  - Kwashiorkor/blood
MH  - Linoleic Acid
MH  - Linoleic Acids/blood/metabolism
MH  - Linoleoyl-CoA Desaturase
MH  - Nigeria
MH  - Oleic Acid
MH  - Oleic Acids/blood
MH  - Phospholipids/blood
MH  - Protein-Energy Malnutrition/*blood/metabolism
MH  - Triglycerides/blood
EDAT- 1986/04/01 00:00
MHDA- 1986/04/01 00:01
CRDT- 1986/04/01 00:00
PHST- 1986/04/01 00:00 [pubmed]
PHST- 1986/04/01 00:01 [medline]
PHST- 1986/04/01 00:00 [entrez]
AID - 10.1007/BF00441868 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1986 Apr;145(1-2):109-15. doi: 10.1007/BF00441868.