PMID- 30898146
OWN - NLM
STAT- MEDLINE
DCOM- 20200422
LR  - 20200422
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Mar 21
TI  - The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell 
      function.
PG  - 103
LID - 10.1186/s13287-019-1186-0 [doi]
LID - 103
AB  - In addition to its primary function to provide movement and maintain posture, the 
      skeletal muscle plays important roles in energy and glucose metabolism. In 
      healthy humans, skeletal muscle is the major site for postprandial glucose uptake 
      and impairment of this process contributes to the pathogenesis of type 2 diabetes 
      mellitus (T2DM). A key component to the maintenance of skeletal muscle integrity 
      and plasticity is the presence of muscle progenitor cells, including satellite 
      cells, fibroadipogenic progenitors, and some interstitial progenitor cells 
      associated with vessels (myo-endothelial cells, pericytes, and mesoangioblasts). 
      In this review, we aim to discuss the emerging concepts related to these 
      progenitor cells, focusing on the identification and characterization of distinct 
      progenitor cell populations, and the impact of obesity and T2DM on these cells. 
      The recent advances in stem cell therapies by targeting diabetic and obese muscle 
      are also discussed.
FAU - Teng, Shuzhi
AU  - Teng S
AD  - The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College 
      of Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, 
      People's Republic of China. steng@jlu.edu.cn.
FAU - Huang, Ping
AU  - Huang P
AUID- ORCID: 0000-0001-8062-024X
AD  - The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College 
      of Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, 
      People's Republic of China. huangping@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190321
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
SB  - IM
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology/therapy
MH  - Humans
MH  - Muscle, Skeletal/*metabolism/pathology
MH  - Obesity/*metabolism/pathology/therapy
MH  - Satellite Cells, Skeletal Muscle/*metabolism/pathology/transplantation
MH  - Stem Cell Transplantation
PMC - PMC6427880
OTO - NOTNLM
OT  - Obesity
OT  - Satellite cell
OT  - T2DM
OT  - muscle progenitor cell
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable CONSENT FOR 
      PUBLICATION: Not applicable COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2019/03/23 06:00
MHDA- 2020/04/23 06:00
PMCR- 2019/03/21
CRDT- 2019/03/23 06:00
PHST- 2019/03/23 06:00 [entrez]
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2020/04/23 06:00 [medline]
PHST- 2019/03/21 00:00 [pmc-release]
AID - 10.1186/s13287-019-1186-0 [pii]
AID - 1186 [pii]
AID - 10.1186/s13287-019-1186-0 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2019 Mar 21;10(1):103. doi: 10.1186/s13287-019-1186-0.