PMID- 30899427
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 10
IP  - 16
DP  - 2019 Feb 22
TI  - The value of arterial spin labelling in adults glioma grading: systematic review 
      and meta-analysis.
PG  - 1589-1601
LID - 10.18632/oncotarget.26674 [doi]
AB  - This study aimed to evaluate the diagnostic performance of arterial spin 
      labelling (ASL) in grading of adult gliomas. Eighteen studies matched the 
      inclusion criteria and were included after systematic searches through EMBASE and 
      MEDLINE databases. The quality of the included studies was assessed utilizing 
      Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The quantitative 
      values were extracted and a meta-analysis was subsequently based on a 
      random-effect model with forest plot and joint sensitivity and specificity 
      modelling. Hierarchical summary receiver operating characteristic (HROC) curve 
      analysis was also conducted. The absolute tumour blood flow (TBF) values can 
      differentiate high-grade gliomas (HGGs) from low-grade gliomas (LGGs) and grade 
      II from grade IV tumours. However, it lacked the capacity to differentiate grade 
      II from grade III tumours and grade III from grade IV tumours. In contrast, the 
      relative TBF (rTBF) is effective in differentiating HGG from LGG and in glioma 
      grading. The maximum rTBF (rTBFmax) demonstrated the best results in glioma 
      grading. These results were also reflected in the sensitivity/specificity 
      analysis in which the rTBFmax showed the highest discrimination performance in 
      glioma grading. The estimated effect size for the rTBF was approximately similar 
      between HGGs and LGGs, and grade II and grade III tumours, (-1.46 (-2.00, -0.91), 
      p-value < 0.001), (-1.39 (-1.89, -0.89), p-value < 0.001), respectively; while it 
      exhibited smaller effect size between grade III and grade IV (-1.05 (-1.82, 
      -0.27)), p < 0.05). Sensitivity and specificity analysis replicate these results 
      as well. This meta-analysis suggests that ASL is useful for glioma grading, 
      especially when considering the rTBFmax parameter.
FAU - Alsaedi, Amirah
AU  - Alsaedi A
AD  - Department of Radiology Technology, Taibah University, Medina, KSA.
AD  - Department of Brain Repair & Rehabilitation, Queen Square Institute of Neurology, 
      University College London, London, UK.
FAU - Doniselli, Fabio
AU  - Doniselli F
AD  - Postgraduate School in Radiodiagnostics, Universita degli Studi di Milano, Milan, 
      Italy.
AD  - PhD Course in Clinical Research, Universita degli Studi di Milano, Milan, Italy.
FAU - Jager, Hans Rolf
AU  - Jager HR
AD  - Department of Brain Repair & Rehabilitation, Queen Square Institute of Neurology, 
      University College London, London, UK.
AD  - Lysholm Department of Neuroradiology, The National Hospital for Neurology and 
      Neurosurgery, University College Hospitals NHS Trust, London, UK.
FAU - Panovska-Griffiths, Jasmina
AU  - Panovska-Griffiths J
AD  - Department of Applied Health Research, University College London, London, UK.
FAU - Rojas-Garcia, Antonio
AU  - Rojas-Garcia A
AD  - Department of Applied Health Research, University College London, London, UK.
FAU - Golay, Xavier
AU  - Golay X
AD  - Department of Brain Repair & Rehabilitation, Queen Square Institute of Neurology, 
      University College London, London, UK.
FAU - Bisdas, Sotirios
AU  - Bisdas S
AD  - Department of Brain Repair & Rehabilitation, Queen Square Institute of Neurology, 
      University College London, London, UK.
AD  - Lysholm Department of Neuroradiology, The National Hospital for Neurology and 
      Neurosurgery, University College Hospitals NHS Trust, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20190222
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC6422184
OTO - NOTNLM
OT  - arterial spin labeling
OT  - glioma
OT  - grading
COIS- CONFLICTS OF INTEREST The views expressed in this article are those of the 
      author(s) and not necessarily those of the NHS, the NIHR, or the Department of 
      Health and Social Care.
EDAT- 2019/03/23 06:00
MHDA- 2019/03/23 06:01
PMCR- 2019/02/22
CRDT- 2019/03/23 06:00
PHST- 2018/10/30 00:00 [received]
PHST- 2019/02/01 00:00 [accepted]
PHST- 2019/03/23 06:00 [entrez]
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2019/03/23 06:01 [medline]
PHST- 2019/02/22 00:00 [pmc-release]
AID - 26674 [pii]
AID - 10.18632/oncotarget.26674 [doi]
PST - epublish
SO  - Oncotarget. 2019 Feb 22;10(16):1589-1601. doi: 10.18632/oncotarget.26674. 
      eCollection 2019 Feb 22.