PMID- 30899673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 2214-6237 (Electronic)
IS  - 2214-6237 (Linking)
VI  - 16
DP  - 2019 Jun
TI  - Gestational diabetes mellitus and macrosomia predispose to diabetes in the 
      Lebanese population.
PG  - 100185
LID - 10.1016/j.jcte.2019.100185 [doi]
LID - 100185
AB  - AIMS: The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus 
      (T2DM) worldwide, with Lebanon having 15.8% of its population affected. This 
      study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational Diabetes 
      Mellitus (GDM), and macrosomia as risk factors of T2DM in Lebanon. Such 
      epidemiological and statistical study has never been conducted before in the 
      Middle East region and would be useful for clinical diagnosis. METHODS: Our 
      cohort is comprised of 1453 Lebanese individuals, with 897 controls and 556 
      patients. We tested the correlation between T2DM and the covariates GDM, PCOS, 
      and macrosomia independently. We conducted multinomial logistic regression and 
      cross tabulations with T2DM as an outcome. RESULTS: The results showed a 
      significant association of the independent factors GDM and macrosomia with T2DM. 
      The risk of having T2DM was increased by 4.192 times with the GDM, and by 2.315 
      times with macrosomia respectively. CONCLUSION: In conclusion, GDM and 
      macrosomia, but not PCOS, are significant risk factors for T2DM in our Lebanese 
      cohort. Our results, reported for the first time in the Middle East, present 
      insights into risk factors management and disease prevention.
FAU - Ghassibe-Sabbagh, Michella
AU  - Ghassibe-Sabbagh M
AD  - Department of Natural Sciences, School of Arts and Sciences, Lebanese American 
      University, Beirut, Lebanon.
FAU - Mehanna, Zeina
AU  - Mehanna Z
AD  - Department of Natural Sciences, School of Arts and Sciences, Lebanese American 
      University, Beirut, Lebanon.
FAU - Farraj, Layal Abi
AU  - Farraj LA
AD  - Department of Natural Sciences, School of Arts and Sciences, Lebanese American 
      University, Beirut, Lebanon.
FAU - Salloum, Angelique K
AU  - Salloum AK
AD  - School of Medicine, Lebanese American University, Beirut, Lebanon.
FAU - Zalloua, Pierre A
AU  - Zalloua PA
AD  - School of Medicine, Lebanese American University, Beirut, Lebanon.
AD  - Harvard T.H. Chan School of Public Health, Boston, MA, USA.
LA  - eng
PT  - Journal Article
DEP - 20190220
PL  - Netherlands
TA  - J Clin Transl Endocrinol
JT  - Journal of clinical & translational endocrinology
JID - 101629335
PMC - PMC6406007
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - Lebanese population
OT  - Macrosomia
OT  - Polycystic ovarian syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2019/03/23 06:00
MHDA- 2019/03/23 06:01
PMCR- 2019/02/20
CRDT- 2019/03/23 06:00
PHST- 2018/10/23 00:00 [received]
PHST- 2019/02/17 00:00 [revised]
PHST- 2019/02/18 00:00 [accepted]
PHST- 2019/03/23 06:00 [entrez]
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2019/03/23 06:01 [medline]
PHST- 2019/02/20 00:00 [pmc-release]
AID - S2214-6237(18)30137-6 [pii]
AID - 100185 [pii]
AID - 10.1016/j.jcte.2019.100185 [doi]
PST - epublish
SO  - J Clin Transl Endocrinol. 2019 Feb 20;16:100185. doi: 10.1016/j.jcte.2019.100185. 
      eCollection 2019 Jun.