PMID- 30900509
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20200309
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 15
DP  - 2019 Jan-Dec
TI  - Effects of matrix metalloproteinase inhibitors on N-methyl-D-aspartate receptor 
      and contribute to long-term potentiation in the anterior cingulate cortex of 
      adult mice.
PG  - 1744806919842958
LID - 10.1177/1744806919842958 [doi]
LID - 1744806919842958
AB  - Matrix metalloproteinases (MMPs) have been suggested to contribute to long-term 
      potentiation, behavioral learning, and memory. In the dorsal horn of spinal cord, 
      MMPs were reported to contribute to injury-related changes, and inhibitors of 
      MMPs have been proposed as potential analgesics. However, it is unclear whether 
      MMP inhibitors produce these effects by inhibiting the function of 
      N-methyl-D-aspartate receptor (NMDAR), a key receptor for the induction of 
      long-term potentiation. In this study, we wanted to examine if MMP inhibitors 
      affect NMDAR-mediated excitatory postsynaptic currents in the anterior cingulate 
      cortex of adult mice. Among different subtype inhibitors we used, we found that 
      MMP-9 and MMP-2/9 inhibitors did not change NMDAR-mediated excitatory 
      postsynaptic currents. However, MMP-3 and broad-spectrum MMP inhibitors reduced 
      the NMDAR-mediated excitatory postsynaptic currents. Consistently, MMP-9 and 
      MMP-2/9 inhibitors had no effect on NMDAR-dependent long-term potentiation, but 
      MMP-3 and broad-spectrum MMP inhibitors inhibited the induction of long-term 
      potentiation. Our results suggest that MMP inhibitors may produce their effects 
      by inhibiting NMDAR functions in central synapses.
FAU - Matsuura, Takanori
AU  - Matsuura T
AD  - 1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, 
      Xi'an Jiaotong University, Xi'an, China.
AD  - 2 Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, 
      Ontario, Canada.
AD  - 3 Department of Orthopedics, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Li, Xu-Hui
AU  - Li XH
AD  - 1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, 
      Xi'an Jiaotong University, Xi'an, China.
AD  - 2 Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, 
      Ontario, Canada.
FAU - Tao, Chen
AU  - Tao C
AUID- ORCID: 0000-0003-1956-0553
AD  - 1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, 
      Xi'an Jiaotong University, Xi'an, China.
FAU - Zhuo, Min
AU  - Zhuo M
AUID- ORCID: 0000-0001-9062-3241
AD  - 1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, 
      Xi'an Jiaotong University, Xi'an, China.
AD  - 2 Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, 
      Ontario, Canada.
LA  - eng
GR  - PJT-148648/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
MH  - Animals
MH  - Gyrus Cinguli/drug effects/*metabolism
MH  - Long-Term Potentiation/*drug effects/*physiology
MH  - Male
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Matrix Metalloproteinase Inhibitors/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
PMC - PMC6480992
OTO - NOTNLM
OT  - Matrix metalloproteinase
OT  - N-methyl-D-aspartate receptor
OT  - anterior cingulate cortex
OT  - long-term potentiation
EDAT- 2019/03/23 06:00
MHDA- 2019/08/14 06:00
PMCR- 2019/04/23
CRDT- 2019/03/23 06:00
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/03/23 06:00 [entrez]
PHST- 2019/04/23 00:00 [pmc-release]
AID - 10.1177_1744806919842958 [pii]
AID - 10.1177/1744806919842958 [doi]
PST - ppublish
SO  - Mol Pain. 2019 Jan-Dec;15:1744806919842958. doi: 10.1177/1744806919842958.