PMID- 30901076
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20200203
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 145
IP  - 8
DP  - 2019 Oct 15
TI  - Preexisting musculoskeletal burden and its development under letrozole treatment 
      in early breast cancer patients.
PG  - 2114-2121
LID - 10.1002/ijc.32294 [doi]
AB  - One of the most common adverse events (AEs) occurring during treatment with 
      aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to 
      analyze the influence of preexisting muscle/limb pain and joint pain on the 
      development of AI-induced musculoskeletal AEs. Women eligible for upfront 
      adjuvant endocrine therapy with letrozole were included in the PreFace study, a 
      multicenter phase IV trial. During the first treatment year, they were asked to 
      record musculoskeletal AEs monthly by answering questions regarding pain symptoms 
      and rating the pain intensity on a numeric rating scale from 0 (no pain) to 10 
      (very strong pain). Pain values were compared using nonparametric statistical 
      tests. Overall, 1,416 patients were evaluable. The average pain value over all 
      time points in women with preexisting muscle/limb pain was 4.3 (median 4.3); in 
      those without preexisting pain, it was 2.0 (median 1.7). In patients without 
      preexisting muscle/limb pain, pain levels increased relatively strongly within 
      the first 6 months (mean increase +0.9, p < 0.00001) in comparison with those 
      with preexisting pain (mean increase +0.3, p < 0.001), resulting in a 
      statistically significant difference (p < 0.00001) between the two groups. The 
      development of joint pain was similar in the two groups. Women without 
      preexisting muscle/limb pain or joint pain have the greatest increase in pain 
      after the start of adjuvant AI therapy. Women with preexisting pain have 
      significantly higher pain values. The main increase in pain values takes place 
      during the first 6 months of treatment.
CI  - (c) 2019 UICC.
FAU - Nabieva, Naiba
AU  - Nabieva N
AUID- ORCID: 0000-0002-8065-0649
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Haberle, Lothar
AU  - Haberle L
AUID- ORCID: 0000-0003-4019-9328
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
AD  - Biostatistics Unit, Department of Gynecology, Erlangen University Hospital, 
      Erlangen, Germany.
FAU - Brucker, Sara Y
AU  - Brucker SY
AD  - Department of Gynecology, University of Tubingen, Tubingen, Germany.
FAU - Janni, Wolfgang
AU  - Janni W
AD  - Department of Gynecology, Ulm University Hospital, Ulm, Germany.
FAU - Volz, Bernhard
AU  - Volz B
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Loehberg, Christian R
AU  - Loehberg CR
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
AD  - St. Theresien Hospital, Nuremberg, Germany.
FAU - Hartkopf, Andreas D
AU  - Hartkopf AD
AD  - Department of Gynecology, University of Tubingen, Tubingen, Germany.
FAU - Walter, Christina-Barbara
AU  - Walter CB
AD  - Department of Gynecology, University of Tubingen, Tubingen, Germany.
FAU - Baake, Gerold
AU  - Baake G
AD  - Oncological Medical Practice Pinneberg, Pinneberg, Germany.
FAU - Fridman, Alexander
AU  - Fridman A
AD  - Breast Center, Department of Obstetrics and Gynecology, Cologne University 
      Hospital, Cologne, Germany.
AD  - Evangelisches Krankenhaus Kalk, Cologne, Germany.
FAU - Malter, Wolfram
AU  - Malter W
AD  - Breast Center, Department of Obstetrics and Gynecology, Cologne University 
      Hospital, Cologne, Germany.
FAU - Wuerstlein, Rachel
AU  - Wuerstlein R
AD  - Breast Center, Department of Obstetrics and Gynecology, Cologne University 
      Hospital, Cologne, Germany.
AD  - Breast Center, Department of Gynecology and Obstetrics and CCC Munich, University 
      of Munich (LMU), Munich, Germany.
FAU - Harbeck, Nadia
AU  - Harbeck N
AD  - Breast Center, Department of Obstetrics and Gynecology, Cologne University 
      Hospital, Cologne, Germany.
AD  - Breast Center, Department of Gynecology and Obstetrics and CCC Munich, University 
      of Munich (LMU), Munich, Germany.
FAU - Hoffmann, Oliver
AU  - Hoffmann O
AD  - Department of Gynecology, Essen University Hospital, Essen, Germany.
FAU - Kuemmel, Sherko
AU  - Kuemmel S
AD  - Breast Unit, Essen Mitte Clinics, Evangelische Huyssens-Stiftung/Knappschaft 
      GmbH, Essen, Germany.
FAU - Martin, Bernhard
AU  - Martin B
AD  - Tuttlingen Clinic, Tuttlingen, Germany.
FAU - Thomssen, Christoph
AU  - Thomssen C
AD  - Department of Gynecology, Martin Luther University of Halle-Wittenberg, Halle 
      (Saale), Germany.
FAU - Graf, Heiko
AU  - Graf H
AD  - Helios Clinics Meiningen, Meiningen, Germany.
FAU - Wolf, Christopher
AU  - Wolf C
AD  - Medical Center Ulm, Ulm, Germany.
FAU - Lux, Michael P
AU  - Lux MP
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Bayer, Christian M
AU  - Bayer CM
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Rauh, Claudia
AU  - Rauh C
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Hack, Carolin C
AU  - Hack CC
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Almstedt, Katrin
AU  - Almstedt K
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
AD  - Department of Gynecology, Mainz University Hospital, Mainz, Germany.
FAU - Gass, Paul
AU  - Gass P
AUID- ORCID: 0000-0002-4239-5528
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Heindl, Felix
AU  - Heindl F
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Brodkorb, Tobias
AU  - Brodkorb T
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Lindner, Christoph
AU  - Lindner C
AD  - Agaplesion Diakonie Clinic Hamburg, Hamburg, Germany.
FAU - Kolberg, Hans-Christian
AU  - Kolberg HC
AD  - Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, 
      Germany.
FAU - Krabisch, Petra
AU  - Krabisch P
AD  - Department of Gynecology, Clinic of Chemnitz gGmbH, Chemnitz, Germany.
FAU - Weigel, Michael
AU  - Weigel M
AD  - Department of Gynecology, Leopoldina Hospital Schweinfurt, Schweinfurt, Germany.
FAU - Steinfeld-Birg, Dieter
AU  - Steinfeld-Birg D
AD  - Gynecologic Oncologic Practice Steinfeld-Birg, Augsburg, Germany.
FAU - Kohls, Andreas
AU  - Kohls A
AD  - Protestant County Hospital of Ludwigsfelde-Teltow, Ludwigsfelde-Teltow, Germany.
FAU - Brucker, Cosima
AU  - Brucker C
AD  - Department of Gynecology and Obstetrics, Nuremberg General Hospital, Paracelsus 
      Medical University, Nuremberg, Germany.
FAU - Schulz, Volker
AU  - Schulz V
AD  - Gynecologic Practice abts+partner, Kiel, Germany.
FAU - Fischer, Gunnar
AU  - Fischer G
AD  - Mittweida Hospital gGmbH, Mittweida, Germany.
FAU - Pelzer, Volker
AU  - Pelzer V
AD  - Department of Gynecology, GFO Clinics Bonn, Bonn, Germany.
FAU - Rack, Brigitte
AU  - Rack B
AD  - Department of Gynecology, Ulm University Hospital, Ulm, Germany.
FAU - Beckmann, Matthias W
AU  - Beckmann MW
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Fehm, Tanja
AU  - Fehm T
AD  - Department of Gynecology, University of Tubingen, Tubingen, Germany.
AD  - Department of Gynecology, Heinrich Heine University of Dusseldorf, Dusseldorf, 
      Germany.
FAU - Rody, Achim
AU  - Rody A
AD  - Department of Gynecology, Schleswig-Holstein University Hospital, Campus Lubeck, 
      Schleswig-Holstein, Germany.
FAU - Maass, Nicolai
AU  - Maass N
AD  - Department of Gynecology, Schleswig-Holstein University Hospital, Campus Kiel, 
      Schleswig-Holstein, Germany.
FAU - Hein, Alexander
AU  - Hein A
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
FAU - Fasching, Peter A
AU  - Fasching PA
AUID- ORCID: 0000-0003-4885-8471
AD  - Department of Gynecology, Erlangen University Hospital, Friedrich Alexander 
      University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 
      Erlangen, Germany.
LA  - eng
PT  - Clinical Trial, Phase IV
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190402
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Aromatase Inhibitors)
RN  - 7LKK855W8I (Letrozole)
SB  - IM
MH  - Aged
MH  - Aromatase Inhibitors/adverse effects/therapeutic use
MH  - Arthralgia/chemically induced/physiopathology
MH  - Breast Neoplasms/*drug therapy/physiopathology
MH  - Female
MH  - Humans
MH  - Letrozole/adverse effects/*therapeutic use
MH  - Middle Aged
MH  - Musculoskeletal Pain/chemically induced/*physiopathology
MH  - Pain Measurement/methods
MH  - Postmenopause/*drug effects/physiology
MH  - Time Factors
OTO - NOTNLM
OT  - aromatase inhibitor
OT  - arthralgia/joint pain
OT  - breast cancer
OT  - endocrine treatment/therapy
OT  - letrozole
OT  - myalgia/muscle and limb pain
EDAT- 2019/03/23 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/03/23 06:00
PHST- 2018/07/09 00:00 [received]
PHST- 2018/12/16 00:00 [revised]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/03/23 06:00 [entrez]
AID - 10.1002/ijc.32294 [doi]
PST - ppublish
SO  - Int J Cancer. 2019 Oct 15;145(8):2114-2121. doi: 10.1002/ijc.32294. Epub 2019 Apr 
      2.