PMID- 30901406
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20190715
IS  - 1930-613X (Electronic)
IS  - 0026-4075 (Linking)
VI  - 184
IP  - Suppl 1
DP  - 2019 Mar 1
TI  - Biomechanics of Blast TBI With Time-Resolved Consecutive Primary, Secondary, and 
      Tertiary Loads.
PG  - 195-205
LID - 10.1093/milmed/usy344 [doi]
AB  - Blast-induced traumatic brain injury (bTBI) has become a signature casualty of 
      recent military operations. In spite of significant clinical and preclinical TBI 
      research, current understanding of injury mechanisms and short- and long-term 
      outcomes is limited. Mathematical models of bTBI biomechanics may help in better 
      understanding of injury mechanisms and in the development of improved 
      neuroprotective strategies. Until present, bTBI has been analyzed as a single 
      event of a blast pressure wave propagating through the brain. In many bTBI 
      events, the loads on the body and the head are spatially and temporarily 
      distributed, involving the primary intracranial pressure wave, followed by the 
      head rotation and then by head impact on the ground. In such cases, the brain 
      microstructures may experience time/space distributed (consecutive) damage and 
      recovery events. The paper presents a novel multiscale simulation framework that 
      couples the body/brain scale biomechanics with micro-scale mechanobiology to 
      study the effects of micro-damage to neuro-axonal structures. Our results show 
      that the micro-mechanical responses of neuro-axonal structures occur sequentially 
      in time with "damage" and "relaxation" periods in different parts of the brain. A 
      new integrated computational framework is described coupling the brain-scale 
      biomechanics with micro-mechanical damage to axonal and synaptic structures.
CI  - (c) Association of Military Surgeons of the United States 2019. All rights 
      reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Przekwas, Andrzej
AU  - Przekwas A
AD  - CFD Research Corp., 701 McMillan Way NW, Huntsville, AL.
FAU - Garimella, Harsha T
AU  - Garimella HT
AD  - CFD Research Corp., 701 McMillan Way NW, Huntsville, AL.
FAU - Tan, X Gary
AU  - Tan XG
AD  - US Naval Research Laboratory, 4555 Overlook Ave., Washington, DC.
FAU - Chen, Z J
AU  - Chen ZJ
AD  - CFD Research Corp., 701 McMillan Way NW, Huntsville, AL.
FAU - Miao, Yuyang
AU  - Miao Y
AD  - CFD Research Corp., 701 McMillan Way NW, Huntsville, AL.
FAU - Harrand, Vincent
AU  - Harrand V
AD  - CFD Research Corp., 701 McMillan Way NW, Huntsville, AL.
FAU - Kraft, Reuben H
AU  - Kraft RH
AD  - Pennsylvania State University, 320 Leonhard Building, University Park, PA.
FAU - Gupta, Raj K
AU  - Gupta RK
AD  - DoD Blast Program Coordinating Office, US Army MRMC, 504 Scott Street, Fort 
      Detrick, MD.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
SB  - IM
MH  - Biomechanical Phenomena/*physiology
MH  - *Biophysics
MH  - Blast Injuries/classification/*complications
MH  - Brain Injuries, Diffuse/physiopathology
MH  - Brain Injuries, Traumatic/classification/*complications
MH  - Computer Simulation
MH  - Humans
MH  - Models, Theoretical
MH  - Time Factors
OTO - NOTNLM
OT  - Blast injury
OT  - injury biomechanics
OT  - mathematical model
OT  - multiscale modeling
OT  - traumatic brain injury
EDAT- 2019/03/23 06:00
MHDA- 2019/07/16 06:00
CRDT- 2019/03/23 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/10/29 00:00 [revised]
PHST- 2019/03/23 06:00 [entrez]
PHST- 2019/03/23 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
AID - 5418655 [pii]
AID - 10.1093/milmed/usy344 [doi]
PST - ppublish
SO  - Mil Med. 2019 Mar 1;184(Suppl 1):195-205. doi: 10.1093/milmed/usy344.