PMID- 30901835
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 6
DP  - 2019 Mar 21
TI  - Effect of Resveratrol-Enriched Rice on Skin Inflammation and Pruritus in the 
      NC/Nga Mouse Model of Atopic Dermatitis.
LID - 10.3390/ijms20061428 [doi]
LID - 1428
AB  - Resveratrol-enriched rice (RR) was developed using genetic engineering to combine 
      the properties of resveratrol and rice. To evaluate the effect of RR on pruritic 
      skin inflammation in atopic dermatitis (AD)-like skin lesions, we used 
      dinitrochlorobenzene (DNCB)-induced NC/Nga mice and an in vitro 3D skin model. 
      Normal rice (NR), resveratrol, and RR were topically applied to mice dorsal skin, 
      following which the dermatitis index and scratching frequency were calculated. 
      Histological examination was performed by hematoxylin and eosin and 
      immunohistochemistry staining of IL-31 level. The level of immunoglobulin E (IgE) 
      and IL-31 in the serum was determined by enzyme-linked immunosorbent assay 
      (ELISA). The cytotoxicity of RR and the expression levels of pro-inflammatory 
      cytokines were also determined in cultured human keratinocytes and a 3D skin 
      model. RR significantly reduced scratching frequency, decreased the dermatitis 
      severity and trans-epidermal water loss (TEWL) and improved skin hydration in 
      DNCB-induced NC/Nga mice. RR also significantly decreased serum IL-31 and IgE 
      levels and suppressed the production of IL-6 in human keratinocytes and the 3D 
      skin model. Our study indicates that the synergistic effect of rice and 
      resveratrol manifested by the topical application of RR can serve as a potential 
      alternative therapy for chronic skin inflammatory diseases such as AD.
FAU - Kang, Min Cheol
AU  - Kang MC
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. mincjf07@gmail.com.
FAU - Cho, Kyohee
AU  - Cho K
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. kcho3138@gmail.com.
FAU - Lee, Jae Hyuk
AU  - Lee JH
AUID- ORCID: 0000-0002-4304-0198
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. wogur6378@naver.com.
FAU - Subedi, Lalita
AU  - Subedi L
AUID- ORCID: 0000-0003-4851-7650
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. subedilali@gmail.com.
FAU - Yumnam, Silvia
AU  - Yumnam S
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. silviayumnam@gmail.com.
FAU - Kim, Sun Yeou
AU  - Kim SY
AUID- ORCID: 0000-0001-8044-5613
AD  - College of Pharmacy, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon 
      21936, Korea. sunnykim@gachon.ac.kr.
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon 
      21565, Korea. sunnykim@gachon.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20190321
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
RN  - 0 (interleukin-31, mouse)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Cytokines/metabolism
MH  - Dermatitis/*drug therapy/etiology/pathology
MH  - Disease Models, Animal
MH  - Immunoglobulin E/blood/immunology
MH  - Inflammation Mediators
MH  - Interleukins/blood
MH  - Mice
MH  - Oryza/*chemistry
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Pruritus/*drug therapy/etiology/pathology
PMC - PMC6471349
OTO - NOTNLM
OT  - NC/Nga
OT  - atopic dermatitis
OT  - dinitrochlorobenzene
OT  - resveratrol-enriched rice
OT  - skin inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2019/03/25 06:00
MHDA- 2019/07/17 06:00
PMCR- 2019/03/01
CRDT- 2019/03/24 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/03/15 00:00 [revised]
PHST- 2019/03/17 00:00 [accepted]
PHST- 2019/03/24 06:00 [entrez]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - ijms20061428 [pii]
AID - ijms-20-01428 [pii]
AID - 10.3390/ijms20061428 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Mar 21;20(6):1428. doi: 10.3390/ijms20061428.