PMID- 30903709
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20231213
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 46
IP  - 8
DP  - 2019 Aug
TI  - Is melanocyte density our last hope? Comparison of histologic features of 
      photodamaged skin and melanoma in situ after staged surgical excision with 
      concurrent scouting biopsies.
PG  - 555-562
LID - 10.1111/cup.13462 [doi]
AB  - Differentiating melanocytic hyperplasia (MH) on photodamaged skin from junctional 
      lentiginous melanocytic proliferations (JLMP), early evolving melanoma in situ 
      (MIS), or the periphery of a lesion of MIS on staged excision can be challenging. 
      Although previous cross-sectional studies have elucidated important criteria for 
      distinguishing MH on photodamaged skin from more concerning lesions, this study 
      highlights a technique to treat JLMP and MIS with staged mapped excision and 
      baseline scouting biopsies of adjacent nonlesional photodamaged skin to assist in 
      determination of surgical margin clearance. Additionally, we compare the lesional 
      and photodamaged control biopsies from the same patient to evaluate relevant 
      histologic criteria that may be used to distinguish MH in photodamaged skin from 
      JLMP/MIS, while minimizing confounding factors. There was a statistically 
      significant difference (P </= 0.05) found for melanocyte density, irregular 
      melanocyte distribution, melanocyte clustering, follicular infundibulum 
      involvement, and nesting. However, criteria such as nesting, epithelioid cells 
      and melanocyte clustering were seen in both photodamaged skin and MIS. These 
      findings underscore the fact that histologic features of photodamaged skin can 
      overlap with the histopathological features of MIS. Of all of the criteria 
      evaluated, melanocytic density was the most objective histologic criterion and 
      did not show overlap between the sun-damaged and JLMP/MIS groups.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Speiser, Jodi
AU  - Speiser J
AUID- ORCID: 0000-0002-0736-9076
AD  - Department of Pathology, Loyola University Chicago Stritch School of Medicine, 
      Maywood, Illinois.
FAU - Tao, Joy
AU  - Tao J
AD  - Division of Dermatology, Department of Medicine, Loyola University Chicago 
      Stritch School of Medicine, Maywood, Illinois.
FAU - Champlain, Amanda
AU  - Champlain A
AD  - Division of Dermatology, Department of Medicine, Loyola University Chicago 
      Stritch School of Medicine, Maywood, Illinois.
FAU - Moy, Lauren
AU  - Moy L
AD  - Division of Dermatology, Department of Medicine, Loyola University Chicago 
      Stritch School of Medicine, Maywood, Illinois.
FAU - Janeczek, Monica
AU  - Janeczek M
AD  - Division of Dermatology, Department of Medicine, Loyola University Chicago 
      Stritch School of Medicine, Maywood, Illinois.
FAU - Omman, Reeba
AU  - Omman R
AD  - Department of Pathology, Loyola University Chicago Stritch School of Medicine, 
      Maywood, Illinois.
FAU - Mudaliar, Kumaran
AU  - Mudaliar K
AUID- ORCID: 0000-0003-0077-2978
AD  - Department of Pathology, Loyola University Chicago Stritch School of Medicine, 
      Maywood, Illinois.
FAU - Tung, Rebecca
AU  - Tung R
AD  - Division of Dermatology, Department of Medicine, Loyola University Chicago 
      Stritch School of Medicine, Maywood, Illinois.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20190425
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanocytes/*pathology
MH  - *Melanoma/pathology/surgery
MH  - Middle Aged
MH  - Skin/*pathology
MH  - Skin Aging/*pathology
MH  - *Skin Neoplasms/pathology/surgery
MH  - Melanoma, Cutaneous Malignant
OTO - NOTNLM
OT  - atypical junctional melanocytic hyperplasia
OT  - lentigo maligna
OT  - melanoma in situ
OT  - scouting biopsy
OT  - slow Mohs
OT  - staged excision
EDAT- 2019/03/25 06:00
MHDA- 2020/02/14 06:00
CRDT- 2019/03/24 06:00
PHST- 2018/06/18 00:00 [received]
PHST- 2019/03/01 00:00 [revised]
PHST- 2019/03/08 00:00 [accepted]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2019/03/24 06:00 [entrez]
AID - 10.1111/cup.13462 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2019 Aug;46(8):555-562. doi: 10.1111/cup.13462. Epub 2019 Apr 25.