PMID- 30903960
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20201104
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 67
DP  - 2019 May
TI  - Gestational caloric restriction improves redox homeostasis parameters in the 
      brain of Wistar rats: a screening from birth to adulthood.
PG  - 138-148
LID - S0955-2863(18)30621-1 [pii]
LID - 10.1016/j.jnutbio.2019.02.002 [doi]
AB  - Caloric restriction (CR) improves health and life span in animal models. Although 
      CR effects in adult life are well described, little is known about effects on 
      offspring when applied during gestation. Pregnancy is a remarkable period of 
      life, alterations in this stage lead to lifelong consequences, some of which, 
      associated to redox unbalance. Furthermore, gestational overweight is a growing 
      issue that can lead to detrimental outcomes. To address this issue, we divided 
      pregnant rats into control (ad libitum food) and CR groups, which received 20% 
      less food than control. Micronutrients consumption was equalized between groups 
      by oral gavage. Cerebellum, prefrontal cortex, hippocampus, and hypothalamus were 
      evaluated on post-natal day (PND) 0, 7, 21, and 60. We observed increased 
      oxidants content on PND0 in all brain structures, except for the cerebellum. Key 
      enzymatic antioxidant defenses showed decreased activity on PND0. Interestingly, 
      on PND60, we observed a positive modulation of most antioxidant enzymes, 
      especially on the prefrontal cortex and hippocampus. Non-enzymatic antioxidant 
      defenses were decreased at birth and increased during development and adult age. 
      Lipid peroxidation was increased at birth on most structures, and the effect was 
      abolished thereafter. In the prefrontal cortex, lipid peroxidation was unaltered 
      at birth and diminished thereafter, while protein oxidation was increased on PND0 
      and decreased on PND60. Protein oxidation was also decreased in the cerebellum at 
      adult age. Our results shown controlled gestational CR to improve antioxidant 
      defenses and protect offspring's brain from oxidative stress, especially in 
      adulthood, as a result of developmental metabolic programming.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Stone, Vinicius
AU  - Stone V
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Crestani, Mariana Scortegagna
AU  - Crestani MS
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Saccomori, Andre Brum
AU  - Saccomori AB
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Marino Dal Magro, Barbara
AU  - Marino Dal Magro B
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Maurmann, Rafael Moura
AU  - Maurmann RM
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - August, Pauline Maciel
AU  - August PM
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Dos Santos, Bernardo Gindri
AU  - Dos Santos BG
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Klein, Caroline Peres
AU  - Klein CP
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Hackenhaar, Fernanda Schaefer
AU  - Hackenhaar FS
AD  - Programa de Pos-graduacao em Biologia Molecular e Celular, Instituto de 
      Biociencias, Universidade Federal do Rio Grande do Sul. Avenida Bento Goncalves, 
      9500-Predio 43422 (laboratorio 208B), CEP 91501970, Porto Alegre, RS, Brazil.
FAU - da Silveira Benfato, Mara
AU  - da Silveira Benfato M
AD  - Programa de Pos-graduacao em Biologia Molecular e Celular, Instituto de 
      Biociencias, Universidade Federal do Rio Grande do Sul. Avenida Bento Goncalves, 
      9500-Predio 43422 (laboratorio 208B), CEP 91501970, Porto Alegre, RS, Brazil; 
      Departamento de Biofisica, Instituto de Biociencias, Universidade Federal do Rio 
      Grande do Sul. Avenida Bento Goncalves, 9500-Predio 43422 (laboratorio 208B), CEP 
      91501970, Porto Alegre, RS, Brazil.
FAU - Matte, Cristiane
AU  - Matte C
AD  - Programa de Pos-graduacao em Ciencias Biologicas: Bioquimica, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul. Rua Ramiro 
      Barcelos, 2600-Anexo (laboratorio 23), CEP 90035-003, Porto Alegre, RS, Brazil; 
      Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2600-Anexo (laboratorio 23), 
      CEP 90035-003, Porto Alegre, RS, Brazil; Programa de Pos-graduacao em Ciencias 
      Biologicas: Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul. Rua Sarmento Leite, 500, CEP 90050-170, Porto 
      Alegre, RS, Brazil. Electronic address: matte@ufrgs.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190220
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Antioxidants)
RN  - 0 (Oxidants)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/metabolism
MH  - Brain/*metabolism
MH  - *Caloric Restriction
MH  - Female
MH  - Homeostasis
MH  - Lipid Peroxidation
MH  - Maternal Nutritional Physiological Phenomena
MH  - Oxidants/metabolism
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Rats, Wistar
MH  - Weight Gain
OTO - NOTNLM
OT  - Dietary restriction
OT  - Intrauterine environment
OT  - Metabolic programming
OT  - Pregnancy
OT  - Redox status
EDAT- 2019/03/25 06:00
MHDA- 2020/11/05 06:00
CRDT- 2019/03/24 06:00
PHST- 2018/06/26 00:00 [received]
PHST- 2018/10/11 00:00 [revised]
PHST- 2019/02/11 00:00 [accepted]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2019/03/24 06:00 [entrez]
AID - S0955-2863(18)30621-1 [pii]
AID - 10.1016/j.jnutbio.2019.02.002 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2019 May;67:138-148. doi: 10.1016/j.jnutbio.2019.02.002. Epub 
      2019 Feb 20.