PMID- 30906450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 4
DP  - 2019 Apr
TI  - Electroacupuncture for chemotherapy-induced anorexia through humoral appetite 
      regulation: A preliminary experimental study.
PG  - 2587-2597
LID - 10.3892/etm.2019.7250 [doi]
AB  - Chemotherapy-induced anorexia (CIA), which may lead to severe 
      nutrition-associated problems, is a common complication associated with 
      anti-cancer therapies. In the present study, the anti-anorexigenic effect of 
      electroacupuncture (EA) was explored through assessing a change in 
      appetite-associated peptides and c-Fos expression in a rat model of 
      cisplatin-induced anorexia. In order to identify the most effective acupuncture 
      point, 20 male Wistar rats (divided into five groups including the normal saline 
      control, cisplatin only control and three groups according to the acupoints 
      stimulated) were subjected to EA for 10 min at CV12, ST36 or PC6 daily for 4 
      days. Subsequently, the rats received intraperitoneal injections of cisplatin (6 
      mg/kg) to induce CIA. Food intake and reduction in body weight gain as the 
      anorexia-associated outcomes were assessed daily for up to 3 days after cisplatin 
      injection, and CV12 was eventually chosen as the most effective acupoint to test 
      the anti-anorexigenic effect of EA. Furthermore, food intake, body weight and the 
      concentrations of appetite-associated peptides, including ghrelin, 
      cholecystokinin (CCK) and 5-hydroxytryptamine (5-HT), in addition to c-Fos 
      expression, were comparatively assessed between the CV12 EA group (n=6; rats 
      treated with EA at CV12 daily for 4 days) and a control group (n=6; rats without 
      treatment). The results indicated that the CV12 EA group exhibited a better 
      outcome regarding food intake and body weight compared with the controls. 
      Although there was no statistically significant difference observed, the 
      secretion of serum ghrelin and CCK was increased in the CV12 EA group compared 
      with that in the control group. The plasma level of 5-HT after cisplatin 
      injection in the CV12 EA group was lower compared with that in the control, 
      although no statistical significance was reached. Although not statistically 
      significant, the expression of c-Fos protein in the nucleus tractus solitarius 
      (NTS) was reduced in the CV12 EA rats. In addition, the hypothalamic mRNA levels 
      of brain-derived neurotrophic factor (BDNF) were significantly increased in the 
      CV12 EA group. In the hypothalamus, the expression of neuropeptide Y mRNA 
      slightly increased in the cisplatin + CV12 EA group compared with the cisplatin 
      only control group. In conclusion, the anti-anorexigenic effect of EA on CIA may 
      be associated with an increase in the secretion of ghrelin and CCK and a decrease 
      in the secretion of 5-HT into the serum, a reduction of c-Fos expression in the 
      NTS and an increase in BDNF mRNA expression in the hypothalamus.
FAU - Kang, Ki Sung
AU  - Kang KS
AD  - Department of Preventive Medicine, College of Korean Medicine, Gachon University, 
      Seongnam, Gyeonggi-do 13120, Republic of Korea.
FAU - Huh, Wonsang
AU  - Huh W
AD  - Department of Preventive Medicine, College of Korean Medicine, Gachon University, 
      Seongnam, Gyeonggi-do 13120, Republic of Korea.
FAU - Bang, Yeojin
AU  - Bang Y
AD  - College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 
      Seongnam, Gyeonggi-do 13488, Republic of Korea.
FAU - Choi, Hyun Jin
AU  - Choi HJ
AD  - College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, 
      Seongnam, Gyeonggi-do 13488, Republic of Korea.
FAU - Baek, Ji Yun
AU  - Baek JY
AD  - Department of Preventive Medicine, College of Korean Medicine, Gachon University, 
      Seongnam, Gyeonggi-do 13120, Republic of Korea.
FAU - Song, Ji Hoon
AU  - Song JH
AD  - Department of Medicine, University of Ulsan College of Medicine, Seoul 05505, 
      Republic of Korea.
FAU - Kang, Jung Won
AU  - Kang JW
AD  - Department of Acupuncture and Moxibustion, College of Korean Medicine, Kyung Hee 
      University, Seoul 02447, Republic of Korea.
FAU - Kim, Tae-Hun
AU  - Kim TH
AD  - Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee 
      University, Seoul 02447, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6425152
OTO - NOTNLM
OT  - 5-hydroxytryptamine
OT  - appetite
OT  - cancer
OT  - chemotherapy-induced anorexia
OT  - cisplatin
OT  - electroacupuncture
OT  - ghrelin
EDAT- 2019/03/25 06:00
MHDA- 2019/03/25 06:01
PMCR- 2019/02/07
CRDT- 2019/03/26 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2018/09/13 00:00 [accepted]
PHST- 2019/03/26 06:00 [entrez]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2019/03/25 06:01 [medline]
PHST- 2019/02/07 00:00 [pmc-release]
AID - ETM-0-0-7250 [pii]
AID - 10.3892/etm.2019.7250 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Apr;17(4):2587-2597. doi: 10.3892/etm.2019.7250. Epub 2019 Feb 
      7.