PMID- 30906463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 4
DP  - 2019 Apr
TI  - MicroRNA target gene prediction of ischemic stroke by using variational Bayesian 
      inference for Gauss mixture model.
PG  - 2734-2740
LID - 10.3892/etm.2019.7262 [doi]
AB  - MicroRNAs (miRNAs) as biomarkers of numerous diseases, are a novel group of 
      single-stranded, non-coding small RNA molecules, which can regulate the gene 
      expression and transcription or translation of target genes. Therefore, 
      accurately identifying miRNAs and predicting their potential target genes 
      correlated with ischemic stroke contribute to quick understanding and diagnosis 
      of the pathogenesis of ischemic stroke. In order to identify the targets of 
      miRNAs, the differential expression and expression profiling of mRNAs in genome 
      are integrated by using the Gene Expression Omnibus (GEO) database and limma 
      package. Furthermore, the probabilistic scoring approach called TargetScore, is 
      proposed as a promising new technique combined with the expression and sequence 
      information of the known genes. In this study, the priori and posterior 
      probabilities of target genes were obtained by Variational Bayesian-Gaussian 
      Mixture Model (VB-GMM). Consequently, the target genes of miR-124, miR-221 and 
      miR-223, correlated with ischemic stroke, were predicted using the new target 
      prediction algorithm. Ultimately, the comparable downregulation target genes were 
      obtained by integrating the transcendental and posterior values.
FAU - Wu, Jun
AU  - Wu J
AD  - Department of Neurology, Xiangyang Central Hospital, Xianyang, Shanxi 712000, 
      P.R. China.
FAU - Wang, Bin
AU  - Wang B
AD  - Jinan ZhangQiu District Hospital of TCM, Jinan, Shandong 250200, P.R. China.
FAU - Zhou, Ju
AU  - Zhou J
AD  - Jinan ZhangQiu District Hospital of TCM, Jinan, Shandong 250200, P.R. China.
FAU - Ji, Fajing
AU  - Ji F
AD  - Department of Rehabilitation Medicine, Shanxian Central Hospital, Heze, Shandong 
      274300, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190213
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6425264
OTO - NOTNLM
OT  - bioinformatics
OT  - ischemic stroke
OT  - microRNA
OT  - microRNA expression profile
OT  - target gene
EDAT- 2019/03/25 06:00
MHDA- 2019/03/25 06:01
PMCR- 2019/02/13
CRDT- 2019/03/26 06:00
PHST- 2018/05/28 00:00 [received]
PHST- 2019/01/31 00:00 [accepted]
PHST- 2019/03/26 06:00 [entrez]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2019/03/25 06:01 [medline]
PHST- 2019/02/13 00:00 [pmc-release]
AID - ETM-0-0-7262 [pii]
AID - 10.3892/etm.2019.7262 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Apr;17(4):2734-2740. doi: 10.3892/etm.2019.7262. Epub 2019 Feb 
      13.