PMID- 30907074
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20191023
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Print)
IS  - 1755-375X (Linking)
VI  - 97
IP  - 6
DP  - 2019 Sep
TI  - Semi-automated quantification of geographic atrophy with blue-light 
      autofluorescence and spectral-domain optical coherence tomography: a comparison 
      between the region finder and the advanced retinal pigment epithelium tool in the 
      clinical setting.
PG  - e887-e895
LID - 10.1111/aos.14085 [doi]
AB  - PURPOSE: To compare inter- and intraobserver reliability and intermodality 
      agreement on quantification of geographic atrophy, using two routinely available 
      quantification tools, based on blue-light fundus autofluorescence (BAF) and 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: Quantifications 
      of atrophic lesions within the central 5 mm of 30 eyes from 30 patients (mean 
      age: 76.1 years) were independently performed by two clinicians on BAF images 
      using the region finder (RF; Heidelberg Engineering) and on SD-OCT using the 
      advanced retinal pigment epithelium tool (ARPET; Carl Zeiss Meditec) at baseline 
      and follow-up (mean interval: 336 days). Inter- and intraobserver reliability was 
      determined by intraclass correlation coefficients (ICC) and Bland-Altmann plots. 
      Additionally, graders rated the experienced difficulty of each measurement. 
      RESULTS: Intraclass correlation coefficients (ICC) showed excellent inter- and 
      intraobserver reliability with values between 0.994 and 0.998 for RF and slightly 
      higher values for ARPET of 0.997 and 0.999. Bland-Altman plots showed smaller 
      variability for ARPET. Mean interobserver differences (95% CI) for size 
      measurements were -0.11 (-0.27; 0.05) (baseline) and -0.05 mm(2) (-0.18; 0.08) 
      (follow-up) for RF and -0.04 (-0.14; 0.06) and -0.06 mm(2) (-0.14; 0.02) for ARPET. 
      Measurements of lesions were on average 0.57 mm(2) (0.35; 0.79) or 7.6% larger in 
      ARPET. Lesion size between graders did not differ significantly. There was no 
      statistically significant difference in relative enlargement rates between 
      methods. There was poor to moderate agreement between graders when rating the 
      experienced difficulty of each measurement. CONCLUSION: Semi-automated analysis 
      of geographic atrophy with RF and ARPET is equally reliable and reproducible in 
      clinical settings, despite both algorithms require frequent adjustment by users. 
      The ARPET restricts size measurements to the central 5 mm, which limits its 
      ability to fully track GA progression. Results of both tools are not 
      interchangeable as measurements with ARPET result in larger lesion sizes.
CI  - (c) 2019 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on 
      behalf of Acta Ophthalmological Scandinavica Foundation.
FAU - Reumueller, Adrian
AU  - Reumueller A
AUID- ORCID: 0000-0003-4344-4624
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, 
      Austria.
FAU - Sacu, Stefan
AU  - Sacu S
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, 
      Austria.
FAU - Karantonis, Maria Georgia
AU  - Karantonis MG
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, 
      Austria.
FAU - Steiner, Irene
AU  - Steiner I
AD  - Center for Medical Statistics, Informatics, and Intelligent Systems, Section for 
      Medical Statistics, Medical University of Vienna, Vienna, Austria.
FAU - Weigert, Guenther
AU  - Weigert G
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, 
      Austria.
FAU - Schmidt-Erfurth, Ursula
AU  - Schmidt-Erfurth U
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, 
      Austria.
LA  - eng
PT  - Journal Article
DEP - 20190324
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Geographic Atrophy/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
PMC - PMC6767530
OTO - NOTNLM
OT  - advanced RPE tool
OT  - blue-light autofluorescence
OT  - geographic atrophy
OT  - interobserver reliability
OT  - intraobserver reliability
OT  - optical coherence tomography
OT  - outer retinal atrophy
OT  - region finder
OT  - semi-automated quantification
EDAT- 2019/03/25 06:00
MHDA- 2019/09/04 06:00
PMCR- 2019/09/30
CRDT- 2019/03/26 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2019/02/16 00:00 [accepted]
PHST- 2019/03/25 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/03/26 06:00 [entrez]
PHST- 2019/09/30 00:00 [pmc-release]
AID - AOS14085 [pii]
AID - 10.1111/aos.14085 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2019 Sep;97(6):e887-e895. doi: 10.1111/aos.14085. Epub 2019 Mar 
      24.